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Related Experiment Video

Updated: Jun 30, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Objective sleep parameters and cognitive performance in euthymic bipolar disorder: a cross-sectional 21-day

Candice Libourel^1,2, Mathilde Charron^1,3, Victoire Martinot^1,3

¹Optimisation Thérapeutique en Neuropharmacologie, UMR-S 1144, Université Paris Cité, Inserm, Paris, 75006, France.

International Journal of Bipolar Disorders

|June 29, 2026

Summary

Objective sleep disturbances in bipolar disorder (BD) are linked to cognitive impairments. Sleep duration, initiation, and continuity correlate with specific cognitive functions in euthymic BD patients.

Keywords:

Actigraphy Bipolar disorder Cognition Memory Sleep

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Last Updated: Jun 30, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

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Published on: April 26, 2024

Human Circadian Phenotyping and Diurnal Performance Testing in the Real World

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Published on: April 7, 2020

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

Area of Science:

Neuroscience
Psychiatry
Sleep Medicine

Background:

Persistent sleep disturbances in euthymic bipolar disorder (BD) may contribute to cognitive deficits.
While subjective sleep issues are linked to cognition, objective sleep-cognition associations in BD are under-explored.

Purpose of the Study:

To investigate the associations between objective sleep parameters and cognitive performance in euthymic individuals with BD.

Main Methods:

40 euthymic BD patients underwent 21-day actigraphy for objective sleep assessment.
Cognitive performance was measured using the Screen for Cognitive Impairment in Psychiatry (SCIP).
Spearman correlations and multivariable linear regression models were used to analyze associations, with false discovery rate correction.

Main Results:

Assumed sleep duration negatively correlated with overall cognitive scores (SCIP total score).
Total sleep time was associated with delayed verbal learning.
Sleep onset latency showed negative associations with working memory and processing speed.
Wake time after sleep onset (WASO) was negatively associated with verbal fluency.

Conclusions:

Objective sleep duration, initiation, and continuity are associated with distinct cognitive domains in euthymic BD.
Sleep continuity and initiation are important correlates of cognitive functioning in BD, beyond sleep duration alone.
Findings are hypothesis-generating and require replication in larger, longitudinal studies.