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Objective sleep parameters and cognitive performance in euthymic bipolar disorder: a cross-sectional 21-day
Candice Libourel1,2, Mathilde Charron1,3, Victoire Martinot1,3
1Optimisation Thérapeutique en Neuropharmacologie, UMR-S 1144, Université Paris Cité, Inserm, Paris, 75006, France.
International Journal of Bipolar Disorders
|June 29, 2026
Summary
Objective sleep disturbances in bipolar disorder (BD) are linked to cognitive impairments. Sleep duration, initiation, and continuity correlate with specific cognitive functions in euthymic BD patients.
Area of Science:
- Neuroscience
- Psychiatry
- Sleep Medicine
Background:
- Persistent sleep disturbances in euthymic bipolar disorder (BD) may contribute to cognitive deficits.
- While subjective sleep issues are linked to cognition, objective sleep-cognition associations in BD are under-explored.
Purpose of the Study:
- To investigate the associations between objective sleep parameters and cognitive performance in euthymic individuals with BD.
Main Methods:
- 40 euthymic BD patients underwent 21-day actigraphy for objective sleep assessment.
- Cognitive performance was measured using the Screen for Cognitive Impairment in Psychiatry (SCIP).
- Spearman correlations and multivariable linear regression models were used to analyze associations, with false discovery rate correction.
Main Results:
- Assumed sleep duration negatively correlated with overall cognitive scores (SCIP total score).
- Total sleep time was associated with delayed verbal learning.
- Sleep onset latency showed negative associations with working memory and processing speed.
- Wake time after sleep onset (WASO) was negatively associated with verbal fluency.
Conclusions:
- Objective sleep duration, initiation, and continuity are associated with distinct cognitive domains in euthymic BD.
- Sleep continuity and initiation are important correlates of cognitive functioning in BD, beyond sleep duration alone.
- Findings are hypothesis-generating and require replication in larger, longitudinal studies.
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