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Published on: September 13, 2019
Pitfalls in Bone and Soft Tissue Pathology of the Head and Neck: Primary Intraosseous
1Histopathology Department, Middlemore Hospital, Counties Manukau Health, Te Whatu Ora (Health New Zealand), Galbraith Building, 1stFloor, 100 Hospital Road, Auckland, New Zealand. omar.habeeb@tewhatuora.govt.nz.
Purpose:
Because of their relative rarity, bone and soft tissue lesions of the head and neck region can present a diagnostic challenge to anatomic pathologists who practice in a general surgical pathology model-while novel lesions may be unfamiliar to subspecialty head and neck pathologists.
Methods:
This review focuses on a diagnostically confounding neoplasm that arises in the bone (primary intraosseous rhabdomyosarcoma / FUS::TFCP2-rearranged spindle cell rhabdomyosarcoma) and soft tissue (trans-/de-/undifferentiated melanoma) of the head and neck region-each of which can easily be mistaken for more common entities.
Results:
The clinical, radiological, and histopathologic findings (including the molecular pathogenesis) of each neoplasm is discussed-along with selected differential diagnoses.
Conclusion:
The accurate recognition of these neoplasms ensures that patients are reviewed, treated, and followed at the appropriate multidisciplinary meeting.
