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Updated: Jun 30, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

Stress Disorders and Human Papillomavirus-Related Cancer Rates: A Population-Based Cohort Study in Denmark.

Sarah E Weber^1,2, Dóra Körmendiné Farkas³, Sharon M Casey¹

¹Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Clinical Epidemiology

|June 29, 2026

Summary

Individuals with stress disorders have a slightly increased risk of developing human papillomavirus (HPV)-related cancers. This association strengthens over time, highlighting the need for further research into the underlying biological and behavioral links between stress and HPV cancer risk.

Keywords:

cancer cohort studies epidemiology human papillomavirus mental health trauma and stressor related disorders

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Last Updated: Jun 30, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma

Published on: March 11, 2014

Area of Science:

Oncology
Psychiatry
Epidemiology

Background:

Stress disorders are linked to immunosuppression, potentially impairing human papillomavirus (HPV) clearance.
Impaired HPV clearance may increase the risk of developing HPV-related cancers.

Purpose of the Study:

To investigate the association between diagnosed stress disorders and the incidence of HPV-related cancers.
To determine if stress disorders modify the risk of specific HPV-related cancers.

Main Methods:

A population-based cohort study in Denmark (1995-2022) identified patients with stress disorders and matched them to controls.
Cox proportional hazards regression was used to estimate hazard ratios for HPV-related cancers after a 1-year lag period.
Adjustments were made for potential confounders, and analyses were stratified by sex.

Main Results:

Women with stress disorders showed a higher likelihood of any HPV-related cancer (aHR=1.3, 95% CI: 1.1-1.4).
Men with stress disorders had an elevated risk of anal cancer (aHR=1.7, 95% CI: 1.0-2.9).
The association between stress disorders and HPV-related cancer risk increased with younger age at diagnosis and longer follow-up.

Conclusions:

Stress disorders are associated with a slightly elevated risk of HPV-related cancers.
The observed association strengthens with longer follow-up periods.
Further research is needed to elucidate the biological and behavioral pathways linking stress disorders to HPV-related cancer risk.