Pregabalin-Induced Myoclonus in a Patient Without Kidney Dysfunction

Area of Science:

• Neurology
• Pharmacology

Background:

• Pregabalin is widely prescribed for neuropathic pain and seizures.
• Common adverse effects include dizziness and somnolence.
• Renal function influences pregabalin dosing.

Purpose of the Study:

• To report a rare case of positive myoclonus associated with pregabalin use.
• To describe transient neurological deficits preceding myoclonus in a patient without renal dysfunction.

Main Methods:

• Case report presentation.
• Review of patient's medical history and medication.
• Clinical observation of neurological deficits and myoclonus.

Main Results:

• A patient on long-term pregabalin without renal impairment presented with stroke-like transient neurological deficits.
• These deficits were followed by jerking movements consistent with positive myoclonus.
• This presentation is rare, especially compared to negative myoclonus.

Conclusions:

• Pregabalin can cause positive myoclonus, a rare but serious adverse effect.
• Transient neurological deficits may precede myoclonus in pregabalin users.
• Clinicians should consider pregabalin-induced myoclonus in patients presenting with these symptoms.