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Related Experiment Video

Updated: Jul 1, 2026

Tuina Manipulation to Reduce Inflammation and Cartilage Loss in Knee Osteoarthritis Rats
05:50

Tuina Manipulation to Reduce Inflammation and Cartilage Loss in Knee Osteoarthritis Rats

Published on: June 30, 2023

Fructus xanthii Extract Alleviates Osteoarthritis by Preserving Cartilage Integrity.

Xiaohan Dou1, Xiaohui Li1, Haohui Wang2

  • 1Department of Orthopedic Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital; Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences.

Journal of Visualized Experiments : Jove
|June 29, 2026
PubMed
Summary

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Fructus Xanthii extract shows potential chondroprotective effects against osteoarthritis (OA). This study systematically explored its bioactive components and therapeutic targets, offering a promising botanical intervention for OA management.

Area of Science:

  • Pharmacology and Traditional Medicine
  • Genomics and Bioinformatics
  • Biochemistry and Molecular Biology

Background:

  • Osteoarthritis (OA) is a degenerative joint disease with limited disease-modifying treatments.
  • Current interventions primarily manage OA symptoms, not underlying pathology.
  • Novel therapeutic agents are urgently needed for OA intervention.

Purpose of the Study:

  • To investigate the chondroprotective potential of Fructus Xanthii extract against osteoarthritis.
  • To identify the bioactive components and molecular targets of Fructus Xanthii extract.
  • To explore the therapeutic mechanisms of Fructus Xanthii extract in OA.

Main Methods:

  • Non-targeted metabolomics (UHPLC-HRMS/MS) to characterize Fructus Xanthii extract.

Related Experiment Videos

Last Updated: Jul 1, 2026

Tuina Manipulation to Reduce Inflammation and Cartilage Loss in Knee Osteoarthritis Rats
05:50

Tuina Manipulation to Reduce Inflammation and Cartilage Loss in Knee Osteoarthritis Rats

Published on: June 30, 2023

  • Network pharmacology and transcriptomic mining to identify bioactive components and targets.
  • In vivo models (zebrafish, mice) and multi-omics (RNA-seq, ELISA) for validation.

    • Main Results:

    • Characterization of Fructus Xanthii extract's chemical constituents.
    • Identification of core target genes and pathways modulated by the extract.
    • In vivo evidence supporting the chondroprotective effects of Fructus Xanthii extract.

    Conclusions:

    • Fructus Xanthii extract exhibits significant chondroprotective effects in OA models.
    • The study systematically elucidated the molecular mechanisms underlying its therapeutic potential.
    • Fructus Xanthii extract represents a promising botanical candidate for OA intervention.