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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
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Schizophrenia Genetic Liability Drives Chronic Disease Risk in Unaffected Individuals through Immune and Metabolic

Wenming Wei1,2, Bolun Cheng1,2, Dan He1,2

  • 1NHC Key Laboratory of Environment and Endemic Diseases, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, China.

Psychotherapy and Psychosomatics
|June 29, 2026
PubMed
Summary

Individuals with higher genetic risk for schizophrenia (SCZ) show increased risk for chronic diseases like asthma and COPD, linked to shared immune and metabolic pathways. This suggests a psycho-neuro-immune-metabolic connection in SCZ-related physical comorbidity.

Keywords:
Chronic diseaseInflammationMetabolomicsPolygenic risk scoreSchizophrenia

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