Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of Diagnostic Biomarkers Related to Oxidative Stress in Rheumatoid Arthritis.

Current medicinal chemistry·2026
Same author

The role of the subcortical structures in subthreshold depression: evidence from static and dynamic functional connectivity.

Brain structure & function·2026
Same author

Hypnosis reduces decoding accuracy of visual and auditory representations.

Brain research bulletin·2026
Same author

Rational Design of Sequentially Activated Dual-Locked Near-Infrared Fluorescent Probe for Simultaneous Imaging of Cerebral Amyloid-β Plaques and ClO<sup>-</sup> in Alzheimer's Disease.

Analytical chemistry·2026
Same author

Kidney disease in patients with two APOL1 risk variants.

Kidney research and clinical practice·2026
Same author

Pan-cancer expression, methylation, and prognostic significance of α7 nicotinic acetylcholine receptor in tumor immunology.

Biochemistry and biophysics reports·2026
Same journal

A Video Protocol of a Randomized Controlled Clinical Trial - Electrochemotherapy of Cutaneous Metastases with Reduced Dose Bleomycin (BLESS Trial).

Journal of visualized experiments : JoVE·2026
Same journal

A Standardized Ex Vivo Porcine Oromucosal Model for Evaluating Peptide Fluxes.

Journal of visualized experiments : JoVE·2026
Same journal

Lightweight English Text Classification with Deep Learning Based on Complex System Theory.

Journal of visualized experiments : JoVE·2026
Same journal

Integrating Artificial Intelligence-Assisted Translation Support into English Courses: Effects on Translation Accuracy, Perceived Stress, and Anxiety.

Journal of visualized experiments : JoVE·2026
Same journal

A Toxin-Based Counter-Selection System for Markerless Gene Deletion and High-Density Tn5 Transposon Mutagenesis in Pectobacterium brasiliense.

Journal of visualized experiments : JoVE·2026
Same journal

Seamless Multimodal Human-Robot Communication: Integration Techniques in Human-Computer Interaction.

Journal of visualized experiments : JoVE·2026
See all related articles

Related Experiment Videos

Current Incidence and Risk Factors for Polymyxin B-Associated Acute Kidney Injury In Patients With Septic Shock.

Yuxia Teng1, Lijun Ma1, Qian Li2

  • 1Department of EICU, Nanjing First Hospital, Nanjing Medical University.

Journal of Visualized Experiments : Jove
|June 29, 2026
PubMed
Summary
This summary is machine-generated.

Polymyxin B caused acute kidney injury (AKI) in 25% of septic shock patients. Risk factors included obesity and other kidney-damaging medications, highlighting the need for careful monitoring.

Related Experiment Videos

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Infectious Diseases

Background:

  • Septic shock patients face high nephrotoxicity risk from critical illness and last-line antibiotics like polymyxin B.
  • Polymyxin B is crucial for multidrug-resistant gram-negative infections but carries nephrotoxic potential.

Purpose of the Study:

  • To determine the incidence and risk factors of polymyxin B-associated acute kidney injury (AKI) in adult patients with septic shock.
  • To identify patient characteristics and co-interventions associated with increased AKI risk during polymyxin B therapy.

Main Methods:

  • Prospective cohort study of 200 adult patients with microbiologically confirmed multidrug-resistant gram-negative infections receiving intravenous polymyxin B.
  • Standardized polymyxin B dosing and renal monitoring using Kidney Disease Improving Global Outcomes (KDIGO) criteria were applied.
  • Risk factors including body mass index, renal function markers, comorbidities, and concomitant nephrotoxic agent use were analyzed.

Main Results:

  • Acute kidney injury (AKI) developed in 25% of patients, with a median onset 4 days after initiating polymyxin B therapy.
  • Higher baseline body mass index, elevated serum urea and creatinine, reduced glomerular filtration rate, comorbidities, and concurrent nephrotoxic agent use were significant risk factors for AKI.
  • Structured nursing interventions and standardized monitoring facilitated early detection and dose adjustment, mitigating renal dysfunction.

Conclusions:

  • Polymyxin B is associated with a significant incidence of AKI in septic shock patients.
  • Systematic renal surveillance, individualized therapeutic strategies, and therapeutic drug monitoring are essential to minimize polymyxin B-induced nephrotoxicity.
  • Early detection and management of renal dysfunction are critical for improving outcomes in this high-risk population.