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A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

Incidence and outcome of paediatric cardioembolic stroke: a nationwide population-based study

Sarah Juul1,2, Thomas Clement Truelsen3,4, Alexander Bastian Koldborg4

  • 1Department of Neonatology, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.

European Stroke Journal
|June 29, 2026
PubMed

Insights

Cardioembolic stroke accounts for nearly a quarter of childhood arterial ischaemic stroke (AIS). While overall outcomes are similar, definite cardioembolic stroke increases the risk of incomplete neurological recovery, necessitating better prevention.

Area of Science:

  • Pediatric Neurology
  • Cardiology
  • Public Health

Background:

  • Cardiac disease is a primary cause of arterial ischaemic stroke (AIS) in children.
  • Limited data exist on pediatric cardioembolic stroke, its causes, and outcomes.

Purpose of the Study:

  • To investigate the incidence rate of pediatric cardioembolic stroke in Denmark.
  • To identify underlying cardiac diseases associated with pediatric cardioembolic stroke.
  • To evaluate the neurological outcomes of pediatric cardioembolic stroke.

Main Methods:

  • Nationwide registry study of children diagnosed with stroke (2013-2020).
  • Arterial ischaemic stroke (AIS) events confirmed via medical record review and classified using Childhood AIS Standardized Classification and Diagnostic Evaluation (CASCADE) criteria.
  • Neuroimaging and neurological outcomes extracted from medical records with a 2-year follow-up.

Main Results:

  • Cardioembolic stroke comprised 24.6% of pediatric AIS cases (n=31/126), with an incidence rate of 0.28 per 100,000 person-years.
  • Congenital heart diseases were the most frequent underlying condition (83.9%).
  • Neurological impairment rates were similar between cardioembolic and non-cardioembolic AIS (48.4% vs 43.6%), but definite cardioembolic stroke showed a higher risk of impairment (73.3% vs 43.6%).

Conclusions:

  • Cardioembolic stroke represents a significant proportion of pediatric AIS.
  • While overall outcomes may be similar, definite cardioembolic stroke is linked to poorer neurological recovery.
  • Improved preventive strategies are crucial for managing pediatric cardioembolic stroke.
Abstract

Keywords:
arterial ischaemic strokecardiac diseasecardioembolic strokeoutcomepaediatric stroke

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