Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nuclear adaptation in cell migration.

You-Hsuan Liu1, Elena Scarpa1

  • 1Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, United Kingdom.

Current Opinion in Cell Biology
|June 29, 2026
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to: "Neonatal Autonomic and Adrenocorticotropic Features in the Offspring of Mothers in the Gestational Diabetes".

Archives of medical research·2026
Same author

Late Vitamin K Deficiency Bleeding in Infancy: The Time to Ensure Effective Prevention.

Nutrition reviews·2025
Same author

Challenges in assessing bone health in early infancy: a narrative review of existing technologies.

Frontiers in endocrinology·2025
Same author

Navigating High-risk Neonatal Intensive Care Unit (NICU) Care: Insights from the Newborn Behavioral Observation (NBO).

Current pediatric reviews·2025
Same author

Neonatal Autonomic and Adrenocorticotropic Features in the Offspring of Mothers with Gestational Diabetes.

Archives of medical research·2025
Same author

Contemporary Insights and Emerging Paradigms in Sedation and Analgesia Management for Ventilated Newborns.

Current pediatric reviews·2025
Same journal

Emerging role of organelles in cell migration.

Current opinion in cell biology·2026
Same journal

Patterns in motion: Choreographing dynamic cell behaviours during tissue repair.

Current opinion in cell biology·2026
Same journal

Quo vadis reconstituted cell surfaces? Purpose and future perspectives for minimal systems of the cell plasma membrane.

Current opinion in cell biology·2026
Same journal

Nuclear determinants of mRNA and protein isoforms.

Current opinion in cell biology·2026
Same journal

Substrate selectivity as a paradigm shift in mTORC1 signaling.

Current opinion in cell biology·2026
Same journal

I did it my way: the origins of lipid droplet heterogeneity.

Current opinion in cell biology·2026
See all related articles

The cell nucleus integrates mechanical signals, adapting its internal organization to navigate confined spaces. This nuclear adaptation is crucial for cell migration in both normal physiology and disease states.

Area of Science:

  • Cell Biology
  • Biophysics
  • Mechanobiology

Background:

  • Cells navigate complex environments, facing mechanical confinement from physical obstacles.
  • The cell nucleus, the largest organelle, acts as a critical hub for sensing and responding to mechanical cues.
  • Nuclear stiffness influences cell migration, particularly under confinement.

Purpose of the Study:

  • To investigate the role of the nucleus in cellular mechanical signal integration.
  • To explore how subnuclear organization adapts to mechanical stress.
  • To understand the implications of nuclear mechanosensitivity for cell function and migration.

Main Methods:

  • Observational studies of cell behavior in confined environments.
  • Analysis of nuclear morphology and internal organization under mechanical stress.

Related Experiment Videos

  • Correlation of nuclear properties with cell migration efficiency.

    • Main Results:

    • The nucleus is not a passive structure but actively responds to mechanical forces.
    • Subnuclear organization dynamically reorganizes in response to mechanical stress.
    • Nuclear adaptation enhances cellular capabilities for migration and invasion.

    Conclusions:

    • The nucleus is a key mechanosensitive organelle that adapts its structure to environmental challenges.
    • Nuclear mechanoadaptation is vital for cell migration, impacting physiology and disease.
    • Understanding nuclear mechanics offers insights into cell function, development, and disease progression.