Related Experiment Video
Updated: Jul 1, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
Published on: August 24, 2013
Taking progressive biology seriously in the time of B-cells and BTK
1University of Calgary Hotchkiss Brain Institute, Toronto, Canada.
Abstract:
The successful landscape of relapsing remitting multiple sclerosis (RRMS) treatments has revolutionized our conceptualization of the disease. This led to a shifting interest towards finding ways of stopping neurodegeneration in progressive MS. The past decade brought us lots of new definitions, such as compartmentalized inflammation, progression free of relapsing activity and the proposal of MS as a disease continuum. It also brought novel therapeutic candidates, the Bruton´s Tyrosine Kinase inhibitors. Unfortunately, the results (reported and announced) of clinical trials in progressive MS have been underwhelming. A recurring theme that may explain the current state of the field is the handling of classical inflammatory "relapsing biology" in progressive MS populations. Although co-pathology of these processes along with neurodegeneration is expected, the time is ripe to take progressive biology seriously.
Related Concept Videos
Positive Regulator Molecules
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Positive Regulator Molecules
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
ATP and Macromolecule Synthesis
Most macromolecules are composed of single subunits, or building blocks, called monomers. The monomers combine with each other using covalent bonds to form larger molecules known as polymers.
Conversion of...
cAMP-dependent Protein Kinase Pathways

