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The Association Between the Risk Analysis Index of Frailty and Patient Safety Indicators: A Single-System Cohort
Samantha N Machinski1, Hasan Nassereldine2, Stephen John Flinn1
1University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
The Journal of Surgical Research
|June 29, 2026
Summary
This study shows that patient frailty increases the risk and cost of patient safety indicators (PSIs) in hospitals. Addressing frailty is key to reducing healthcare costs and improving patient safety.
Area of Science:
- Gerontology
- Health Services Research
- Patient Safety
Background:
- Frailty is linked to poor outcomes in hospitalized patients.
- The connection between frailty, patient safety indicators (PSIs), and healthcare costs is not well understood.
- This study investigates frailty's impact on PSIs and associated costs.
Purpose of the Study:
- To assess the association between the Risk Analysis Index (RAI) frailty measure and 13 surgical PSIs.
- To estimate the average cost of PSI events per at-risk encounter.
- To understand frailty's role in patient safety and hospital financial performance.
Main Methods:
- Retrospective cohort analysis of electronic health records from a multi-hospital system.
- Included adult inpatients with valid RAI scores at risk for adverse PSI events.
- Used logistic regression to analyze the association between frailty levels and PSI events, estimating costs.
Main Results:
- Frailty significantly increased odds of postoperative sepsis, acute kidney injury requiring dialysis, and respiratory failure.
- Higher patient frailty correlated with increased average costs per PSI event.
- Total estimated annual cost of PSI events across the system reached over $4 million.
Conclusions:
- Frailty is associated with higher rates and costs of PSIs, impacting hospital financial penalties.
- Current metrics in the Hospital-Acquired Condition Reduction Program may unfairly penalize hospitals with frail patient populations.
- Revising program metrics could prevent over-penalization and better reflect hospital care challenges.
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