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Related Experiment Video

Updated: Jul 1, 2026

Reconstruct Human Retinoblastoma In Vitro

Reconstruct Human Retinoblastoma In Vitro

Published on: October 11, 2022

Increasing Familial Retinoblastoma in High-Income Countries Despite Stable Overall Incidence, 2017-2024.

Yael Lustig-Barzelay¹, Dupe S Ademola-Popoola², Mazin Faisal Al-Jadiry³

¹Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer.

Ophthalmology. Retina

|June 29, 2026

Summary

Retinoblastoma (RB) incidence in high-income countries remained stable. However, the proportion of familial RB significantly increased, indicating a growing hereditary role in disease burden.

Keywords:

Disease burden Familial disease Global Retinoblastoma study High income countries Retinoblastoma

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Area of Science:

Ophthalmology
Pediatric Oncology
Genetics

Background:

Retinoblastoma (RB) is the most common primary intraocular malignancy in children.
Understanding RB incidence and its subtypes is crucial for public health planning and genetic counseling.
Previous studies have indicated variations in RB incidence globally.

Purpose of the Study:

To re-evaluate retinoblastoma (RB) incidence in high-income countries (HICs).
To assess changes in the proportion of familial RB between 2017 and 2024.
To inform genetic counseling and surveillance strategies.

Main Methods:

A multicenter, repeated cross-sectional study design was employed.
Data were collected from 33 HICs participating in the Global Retinoblastoma Study in both 2017 and 2024.
Poisson generalized estimating equation models were used to compare RB incidence and familial RB proportions between the two study years.

Main Results:

Overall RB incidence in HICs remained stable from 2017 to 2024 (1:15,408 vs. 1:16,399).
Sporadic RB incidence also showed no significant change.
A significant increase in the proportion of familial RB was observed, rising from 7.1% in 2017 to 10.4% in 2024 (a 46.5% relative increase).

Conclusions:

While overall RB incidence is stable in HICs, the rising proportion of familial RB is notable.
This shift suggests an increasing hereditary contribution to the overall RB disease burden.
These findings have significant implications for genetic counseling and the development of targeted surveillance strategies for hereditary retinoblastoma.