Related Experiment Video
Updated: Jul 1, 2026
Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria
Published on: February 28, 2025
Discovery of cytotoxic 1,4-benzodioxane oxyneolignan analogues from Glechoma longituba
Ming-Ming Yuan1, Xi Wu2, Yang-Bing Zheng2
1Jiangxi University of Chinese Medicine, National Pharmaceutical Engineering Center for Solid Preparations of Chinese Herbal Medicine, Nanchang, 330006, China; Jiangxi Institute for Drug Control, Jiangxi Province Engineering Research Center of Drug and Medical Device Quality, Nanchang, 330029, China.
Abstract:
Six previously undescribed 1,4-benzodioxane oxyneolignans, (±)-glechlongins A-C [(±)-1, (±)-2, (±)-3], were isolated from a whole plant extract of Glechoma longituba. All these compounds featured a non-methylated 1,4-benzodioxane. The structures of the enantiomers were elucidated via HRESIMS, NMR and experimental electronic circular dichroism calculations. Additionally, (±)-1, (±)-2, (±)-3 exhibited significant cytotoxicity against various human cancer cell lines. In particular, the racemate (±)-1 exerted selective and potent proliferation-inhibitory effects on t(8; 21) AML cells. In further mechanistic investigations, compound (±)-1 was found to significantly induce cellular differentiation in t(8; 21) AML by downregulating the expression of the AML1-ETO oncogene and inhibiting its downstream signaling transduction. This study is anticipated to provide an active lead structure for the treatment of t(8; 21) AML.