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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Jul 1, 2026

Phase Contrast Magnetic Resonance Imaging in the Rat Common Carotid Artery
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Reproducibility of Splanchnic Blood Flow Measured Using Phase-Contrast MRI.

Lærke S Gasbjerg1,2, Frederikke H Østergaard1, Rasmus S Rasmussen1

  • 1Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

NMR in Biomedicine
|June 29, 2026
PubMed
Summary
This summary is machine-generated.

Phase-contrast MRI (PC-MRI) reliably measures splanchnic blood flow in key abdominal vessels, demonstrating reproducibility and feasibility for detecting postprandial changes in healthy individuals and type 2 diabetes patients.

Keywords:
MRIPC‐MRIabdomenblood flow

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Area of Science:

  • Medical Imaging
  • Cardiovascular Physiology
  • Gastroenterology

Background:

  • Splanchnic blood flow assessment is crucial for understanding abdominal physiology and pathophysiology.
  • Clinical relevance exists for patients with altered abdominal blood flow, vascular neuropathy, or atherosclerosis.
  • Reliable, non-invasive methods for splanchnic blood flow measurement are needed.

Purpose of the Study:

  • To assess the reproducibility of non-invasive phase-contrast MRI (PC-MRI) for measuring splanchnic blood flow.
  • To evaluate the feasibility of PC-MRI for detecting postprandial blood flow changes.

Main Methods:

  • Utilized 2D PC sequences on 3 Tesla MRI scanners (Siemens and Philips).
  • Measured blood flow in the superior mesenteric artery, celiac trunk, hepatic artery, and portal vein in healthy individuals and type 2 diabetes patients.
  • Assessed reproducibility using coefficient of variation (CoV) and Bland-Altman analysis, and evaluated postprandial changes via oral glucose tolerance tests.

Main Results:

  • PC-MRI showed low intrasubject variability for the superior mesenteric artery, celiac trunk, and portal vein (within-session CoV: 7%-22%, between-session CoV: 16%-26%).
  • Hepatic artery measurements exhibited higher variability (within-session CoV: 12%, between-session CoV: 32%).
  • Glucose ingestion significantly increased blood flow in the superior mesenteric artery (88%) and portal vein (68%), which were robustly detected.

Conclusions:

  • Phase-contrast MRI is a reproducible and feasible technique for measuring blood flow in the superior mesenteric artery, celiac trunk, and portal vein.
  • PC-MRI can effectively detect postprandial changes in splanchnic blood flow.
  • This technique holds promise for clinical applications in patients with altered abdominal blood flow.