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Updated: Jul 1, 2026
Intraoperative Gastroscopy for Tumor Localization in Laparoscopic Surgery for Gastric Adenocarcinoma
Published on: August 9, 2016
Gastric-type Histology Independently Predicts Poor Survival in Surgically-treated Cervical Adenocarcinoma
Ok-Ju Kang1, Yaesol Kim1, So-Hyun Nam1
1Department of Obstetrics & Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
Background/Aim:
This study aimed to evaluate the clinicopathologic characteristics and prognostic impact of gastric-type histology in surgically-treated cervical adenocarcinoma.
Patients And Methods:
This retrospective cohort study included 309 patients with cervical adenocarcinoma who underwent primary surgery between 2011 and 2021. Histologic subtypes were classified as usual-type (n=280) and gastric-type (n=29). Clinicopathologic features and survival outcomes were compared. Multivariable Cox regression models were constructed adjusting for age and postoperative risk stratification.
Results:
Gastric-type tumors were associated with higher rates of locally advanced disease, lymphovascular space invasion, lymph node metastasis, parametrial invasion, and positive margins (all p<0.01). Gastric-type histology was significantly associated with inferior progression-free survival (PFS) and overall survival (OS) (both p<0.001). In multivariable analysis, gastric-type histology independently predicted worse PFS [adjusted hazard ratio (aHR)= 2.13, p=0.01] and OS (aHR=3.10, p=0.003).
Conclusion:
In surgically-treated cervical adenocarcinoma, gastric-type histology independently predicts inferior survival outcomes beyond established postoperative risk factors, supporting the need for histology-specific management strategies.
