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Updated: Jul 1, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Practical Steps Toward Antimicrobial Stewardship for the General Practitioner.

Casey Cazer¹, Amelia Greiner Safi²

¹Department of Clinical Sciences, Cornell University College of Veterinary Medicine Ithaca, NY, USA; Department of Public and Ecosystem Health, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.

The Veterinary Clinics of North America. Small Animal Practice

|June 29, 2026

Summary

This summary is machine-generated.

Companion animal veterinarians can reduce antimicrobial use (AMU) through practical stewardship strategies. This approach enhances patient care while combating antimicrobial resistance in both animals and humans.

Keywords:

Antimicrobial resistance Antimicrobial stewardship Antimicrobial use Behavior Recommendations Tools

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Published on: August 30, 2018

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

Area of Science:

Veterinary Medicine
Antimicrobial Stewardship
One Health

Background:

Antimicrobial resistance (AMR) poses a significant threat to animal and human health.
Companion animal veterinarians are increasingly vital in antimicrobial stewardship and client education.
Reducing unnecessary antimicrobial use (AMU) is crucial for combating AMR.

Purpose of the Study:

To provide practical strategies for veterinarians to reduce AMU.
To maintain high-quality patient care while implementing stewardship principles.
To incorporate behavioral and implementation science to overcome practice barriers.

Main Methods:

Review of American Veterinary Medical Association (AVMA) stewardship principles.
Focus on individual and practice-level commitments.
Integration of disease prevention, judicious prescribing (e.g., "five rights"), AMU practice evaluation, and expertise building.
Application of behavioral and implementation science to address barriers like client expectations and diagnostic limitations.

Main Results:

Provides actionable steps for veterinarians to implement antimicrobial stewardship.
Offers insights into overcoming common barriers to reducing AMU.
Emphasizes a multi-faceted approach combining clinical practice, client education, and behavioral science.

Conclusions:

Veterinarians can effectively advance antimicrobial stewardship in daily practice.
Implementing these strategies helps mitigate the threat of AMR.
This approach supports both animal welfare and public health.