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Related Experiment Video

Updated: Jul 1, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

The neuroimmune system and cognition.

Robyn S Klein¹

¹Canada Excellence Research Chair in Neurovirology & Neuroimmunology, Departments of Microbiology & Immunology, Medicine and Western Institute for Neuroscience, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada. rklein8@uwo.ca.

Nature Immunology

|June 29, 2026

Summary

The neuroimmune system uses immune molecules for brain function, including learning and memory. Understanding these molecules may lead to new treatments for memory disorders.

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Related Experiment Videos

Last Updated: Jul 1, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo

Published on: March 26, 2019

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Area of Science:

Neuroscience
Immunology
Cognitive Science

Background:

The neuroimmune system involves bidirectional communication between neural and immune cells.
Immune molecules like cytokines play crucial roles in homeostatic brain function, including learning and memory.
These processes are vital for neural plasticity, particularly in the hippocampus.

Purpose of the Study:

To explore recent advancements in understanding immune molecules' roles in memory formation.
To discuss the potential of these molecules as therapeutic targets for memory disorders.

Main Methods:

This review synthesizes current literature on neuroimmune interactions and memory.
It examines the molecular mechanisms underlying memory consolidation and spatial navigation.
Focus is placed on the hippocampus and its role in memory processes.

Main Results:

Immune molecules are essential mediators in neural processes underlying learning and memory.
These molecules contribute to synaptic strengthening and neurogenesis.
The hippocampus is a key brain region where these neuroimmune functions are prominent.

Conclusions:

Immune molecules are integral to the molecular mechanisms of memory formation.
Targeting neuroimmune pathways presents a promising strategy for treating memory disorders.