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Updated: Jul 2, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 10, 2011

Impact of methicillin resistance on mortality in Staphylococcus aureus endocarditis: a systematic review and

Durga Shankar Meena1, Deepak Kumar2, Gopal Krishana Bohra2

  • 1Division of Infectious Diseases (Department of General Medicine), All India Institute of Medical Sciences, Jodhpur, India. dsmims14@gmail.com.

Communications Medicine
|June 29, 2026
PubMed
Abstract

Insights

Methicillin-resistant Staphylococcus aureus (MRSA) endocarditis leads to higher short-term mortality compared to methicillin-susceptible S. aureus (MSSA). Major complications were similar between MRSA and MSSA endocarditis patients.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Public Health

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of infective endocarditis.
  • Outcomes for MRSA endocarditis are often poor, but comparative mortality risk versus MSSA is unclear.

Purpose of the Study:

  • To quantify and assess the consistency of the mortality risk associated with MRSA endocarditis compared to MSSA endocarditis.

Main Methods:

  • Systematic review and meta-analysis of studies from PubMed, Embase, Scopus, and Cochrane Library up to November 2025.
  • Random-effects model used to calculate pooled risk ratios (RRs) for mortality.
  • Heterogeneity and publication bias assessed via stratified analyses, meta-regression, funnel plots, and Egger's test.

Main Results:

  • Twenty-four studies including 3291 patients (1011 MRSA, 2280 MSSA) were analyzed.
  • MRSA endocarditis showed significantly higher short-term mortality (30.9% vs 25.6%; RR 1.48).
  • Mortality remained higher in MRSA cases across various subgroup analyses; complications like heart failure, embolic events, stroke, and surgery rates were comparable.

Conclusions:

  • MRSA endocarditis is associated with substantially higher short-term mortality than MSSA endocarditis.
  • This increased mortality risk is consistent across different study designs and patient characteristics.
  • Key complications of endocarditis do not significantly differ between MRSA and MSSA infections.

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