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Clonal Hematopoiesis and Type 2 Diabetes: A Narrative Review
Jian-Jun Liu1, Sylvia Liu1, Resham L Gurung1,2
1Clinical Research Unit, Khoo Teck Puat Hospital, Singapore.
Journal of Diabetes
|June 30, 2026
Summary
Clonal hematopoiesis (CH), an aging-related condition, is linked to cardiovascular diseases and type 2 diabetes. Understanding CH is crucial for managing these interconnected health risks.
Area of Science:
- Hematology
- Cardiology
- Endocrinology
- Gerontology
Background:
- Clonal hematopoiesis (CH) involves expanded hematopoietic cell populations with acquired mutations.
- CH is increasingly recognized as a link between aging, metabolic disorders, and cardiovascular diseases (CVDs).
- CH carriers face elevated risks for type 2 diabetes and poorer CVD prognosis, especially in diabetic patients.
Purpose of the Study:
- To review the intersection of clonal hematopoiesis, aging, and metabolic disorders.
- To explore the association between CH and cardiovascular diseases and diabetes.
- To discuss potential therapeutic interventions and future research directions.
Main Methods:
- This is a narrative review synthesizing existing research.
- Literature search on clonal hematopoiesis, aging, metabolic disorders, and cardiovascular diseases.
- Analysis of preclinical and clinical data on CH and associated conditions.
Main Results:
- CH is causally linked to cardiovascular diseases and type 2 diabetes.
- CH may exacerbate microvascular complications in diabetic patients.
- Metformin and anti-inflammatory drugs show potential in managing CH, but further research is needed.
Conclusions:
- Clonal hematopoiesis represents a significant risk factor for cardiovascular and metabolic diseases.
- Further investigation is required to clarify the role of CH in diabetes complications and to optimize therapeutic strategies.
- Addressing barriers to CH detection is essential for clinical translation.
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