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Multicharged Foldable Plasma Membrane Probes for Precise Cancer Cell Discrimination and Fluorescence-Guided Surgery.

Jiaqi Zuo1, Xuantao Shao1, Chuixi Kong2

  • 1Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Key Laboratory of Advanced Catalysis and Adsoption Materials, College of Chemistry and Materials Science, Zhejiang Normal University, Jinhua 321004, People's Republic of China.

Analytical Chemistry
|June 30, 2026
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Summary
This summary is machine-generated.

Researchers developed a novel fluorescent probe (CSP-BP-CSP) that targets cancer cells by detecting differences in cell membrane viscosity. This probe enables precise cancer identification, long-term tracking, and guided tumor resection.

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Area of Science:

  • Biomedical Engineering
  • Molecular Imaging
  • Cancer Diagnostics

Background:

  • Precise identification and treatment of cancer cells remain a significant clinical challenge.
  • Existing methods often lack specificity and long-term tracking capabilities.
  • Targeting cancer cells based on unique membrane properties offers a promising avenue.

Purpose of the Study:

  • To develop a novel fluorescent probe for specific cancer cell targeting based on plasma membrane viscosity.
  • To enable high-contrast cancer cell recognition, long-term membrane labeling, and apoptosis monitoring.
  • To create a versatile platform for cancer diagnosis, intraoperative navigation, and theranostic applications.

Main Methods:

  • Rational structural design of a multicharged foldable fluorescent probe (CSP-BP-CSP) with a bipyridine bridge and cationic pyridinium units.
  • Utilizing differences in plasma membrane viscosity for selective cell membrane anchoring and minimal internalization.
  • In vivo studies in animal models for tumor accumulation and fluorescence-guided surgery.
  • Application in evaluating the efficacy of deuterium-enriched water as an antitumor agent.

Main Results:

  • The probe (CSP-BP-CSP) demonstrated high-affinity membrane anchoring and minimal cellular internalization, enhancing signal-to-noise ratio for long-term tracking.
  • CSP-BP-CSP sensitively responded to viscosity variations, enabling high-contrast specific cancer cell recognition and prolonged membrane labeling.
  • The probe facilitated real-time apoptosis monitoring via nuclear translocation upon membrane damage.
  • Successful application in animal models for sustained tumor-specific accumulation and fluorescence-guided tumor resection.

Conclusions:

  • The developed probe (CSP-BP-CSP) offers a novel strategy for precise cancer cell identification and treatment monitoring.
  • This molecular platform shows significant potential for theranostic integration, including evaluating antitumor efficacy.
  • The study provides a versatile tool for advancing cancer diagnosis, surgical guidance, and treatment evaluation.