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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

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Published on: July 27, 2022

Preparation and characterization of pre-nanoemulsions encapsulating multiple oil-soluble active substances.

Yuxin Liu¹, Zhenlin Shang¹, Wenxin Hu¹

¹School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing, P. R. China.

Drug Development and Industrial Pharmacy

|June 30, 2026

Summary

A novel Pre-Nanoemulsions (PNEs) system offers a stable, cost-effective method for delivering lipophilic ingredients. This PNEs approach overcomes limitations of traditional nanoemulsions, showing enhanced release and absorption.

Keywords:

Nanoemulsions encapsulation efficiency oil-soluble functional substances stability transdermal properties

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Area of Science:

Nanotechnology
Materials Science
Pharmaceutical Sciences

Background:

Traditional nanoemulsions (NEs) are effective for lipophilic active ingredients but suffer from energy-intensive preparation, instability, and high costs.
Existing NE preparation methods present significant challenges for large-scale, cost-effective applications.

Purpose of the Study:

To introduce a novel Pre-Nanoemulsions (PNEs) system designed to overcome the limitations of conventional nanoemulsion preparation.
To develop a stable, efficient, and low-cost delivery system for lipophilic active ingredients.

Main Methods:

PNEs were formulated using oil phase, surfactant, co-surfactant, and aqueous phase, creating thermodynamically stable isotropic mixtures.
Characterization included particle size, zeta potential, and Polydispersity Index (PDI); stability was assessed via centrifugation, dilution, long-term storage, and Turbiscan analysis.
Sustained release and transdermal absorption capabilities of the PNEs were evaluated.

Main Results:

Optimized PNEs demonstrated favorable characteristics: particle size of 115.8 ± 2.6 nm, zeta potential of -40.4 ± 2.4 mV, and PDI of 0.15 ± 0.02.
PNEs exhibited high encapsulation efficiency for lipophilic substances and robust stability confirmed by multiple tests, including Turbiscan analysis.
Enhanced sustained release and transdermal absorption capabilities were observed for the PNEs.

Conclusions:

The developed PNEs system offers a universal, simple, low-cost, and efficient solution for delivering lipophilic active ingredients.
This PNEs approach effectively addresses the challenges associated with traditional nanoemulsions.
The PNEs system holds significant potential for diverse practical applications across various industries.