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Related Experiment Video

Updated: Jul 1, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

3D-Printed Hollow Microneedle Potentiometric Sensors: A Modular Approach.

Qikun Wei1, Águeda Molinero-Fernández2, Daniel Rojas2

  • 1Department of Chemistry, KTH Royal Institute of Technology, Teknikringen 30, Stockholm SE-114 28, Sweden.

ACS Sensors
|June 30, 2026
PubMed
Summary
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This study introduces a novel modular microneedle sensor using 3D printing for continuous health monitoring. The innovative design ensures reliable ion sensing, overcoming previous fabrication challenges for scalable medical devices.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Microneedle sensors offer minimally invasive continuous health monitoring via skin interstitial fluid.
  • Clinical use is limited by complex fabrication, poor reproducibility, and scalability issues.
  • Existing 3D printing methods face trade-offs between resolution and electrochemical functionality.

Purpose of the Study:

  • To develop a novel modular hollow microneedle (HMN) architecture for improved sensor fabrication.
  • To integrate two 3D printing techniques (MSLA and FFF) to overcome single-modality limitations.
  • To create a reliable, scalable, and low-cost microneedle sensor platform for health monitoring.

Main Methods:

  • Designed a modular HMN architecture separating mechanical and sensing functions.
Keywords:
additive manufacturingelectrochemical sensorsensor customizationsolid contactwearable sensors

Related Experiment Videos

Last Updated: Jul 1, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
08:19

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

  • Utilized Masked Stereolithography (MSLA) for high-resolution HMN shells.
  • Employed Fused Filament Fabrication (FFF) for conductive pillar electrodes, functionalized for ion sensing.
  • Assembled a complete sensing patch with pH and reference electrodes.

    • Main Results:

    • Developed a potentiometric pH-HMN sensor with near-Nernstian response (-55.35 ± 0.54 mV/pH).
    • Achieved high sensor performance: repeatability (RSD=0.61%), reproducibility (RSD=1.16%), and stability (0.37 mV/h).
    • Demonstrated high accuracy in ex vivo rat skin tests (mean absolute difference < 0.05 pH units).

    Conclusions:

    • The modular HMN platform streamlines manufacturing for rapid, low-cost, and scalable production.
    • This approach overcomes limitations of previous fabrication methods, enhancing sensor reliability.
    • The developed platform enables future applications for various ions and analytes, with potential for in vivo testing.