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Updated: Jul 1, 2026
08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
From Premature Adrenarche to Adult Metabolic Risk and Hyperandrogenism: A Systematic Review and Meta-Analysis
Thais Milioni Luciano1, Mariana Peduti Halah1, Luís Eduardo Cruvinel Pinto1
1Department of Pediatrics, Ribeirão Preto Medical School, University of São Paulo/FMRP-USP, São Paulo, Brazil.
The Journal of Clinical Endocrinology and Metabolism
|June 30, 2026
Summary
Women with idiopathic premature adrenarche (IPA) face increased risks of long-term insulin resistance and hyperandrogenism. Early signs of adverse cardiometabolic profiles indicate a need for ongoing health monitoring.
Area of Science:
- Endocrinology
- Metabolic Health
- Reproductive Health
Background:
- Idiopathic premature adrenarche (IPA) is linked to metabolic and reproductive issues.
- Long-term and adult outcomes for IPA require further investigation.
Purpose of the Study:
- To evaluate the association between IPA and metabolic syndrome.
- To assess the link between IPA and polycystic ovarian syndrome (PCOS).
- To examine these relationships in premenarcheal adolescent and adult women.
Main Methods:
- Systematic review and meta-analysis of observational studies.
- Included studies reported outcomes in females with IPA post-menarche.
- Primary outcomes: BMI, insulin resistance, hyperandrogenism markers; GRADE assessed evidence certainty.
Main Results:
- 21 studies (635 IPA, 307 controls) found higher BMI, fasting insulin, and HOMA-IR in IPA individuals.
- Elevated hyperandrogenism markers (Ferriman-Gallwey, DHEAS, FAI) were observed.
- Increased triglycerides, lower HDL, higher leptin, and greater carotid intima-media thickness indicate early cardiometabolic risk.
Conclusions:
- History of IPA increases risk for long-term insulin resistance and hyperandrogenism.
- Early indicators of adverse cardiometabolic profiles are present in IPA.
- Long-term monitoring of women with IPA is recommended.
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