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Related Concept Videos

The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:32

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...
Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight Junctions
Tight...

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Updated: Jul 1, 2026

Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction
10:41

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Published on: May 12, 2016

The nucleus-vacuole junction at a glance.

Pascal Höhne1, Marie Hugenroth1, Maria Bohnert1

  • 1Institute of Cell Dynamics and Imaging and Cells in Motion Interfaculty Centre (CiM), University of Münster, Von-Esmarch-Str. 56, 48149 Münster, Germany.

Journal of Cell Science
|June 30, 2026
PubMed
Summary

The nucleus-vacuole junction (NVJ) in yeast is a key lipid hub that adapts to metabolic signals. This adaptable organelle contact site offers insights into cellular communication and lipid metabolism regulation.

Keywords:
Contact siteLipid dropletLipid transfer proteinNVJNvj1Vac8

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Last Updated: Jul 1, 2026

Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction
10:41

Why Quantification Matters: Characterization of Phenotypes at the Drosophila Larval Neuromuscular Junction

Published on: May 12, 2016

A 3D Cartographic Description of the Cell by Cryo Soft X-ray Tomography
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Published on: March 15, 2021

Nuclear Migration in the Drosophila Oocyte
04:17

Nuclear Migration in the Drosophila Oocyte

Published on: May 13, 2021

Area of Science:

  • Cell biology
  • Molecular biology
  • Yeast genetics

Background:

  • The nucleus-vacuole junction (NVJ) is a critical membrane contact site in yeast.
  • It links the nuclear endoplasmic reticulum and the vacuole, playing a vital role in lipid handling.
  • The NVJ is a hub for lipid metabolism enzymes, lipid transfer proteins, and lipid droplet biogenesis.

Purpose of the Study:

  • To highlight the multifunctionality of the NVJ.
  • To emphasize the metabolic plasticity of the NVJ.
  • To illustrate the NVJ's integration into the broader cellular contact site network.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of protein localization and function at the NVJ.
  • Discussion of metabolic regulation of organelle contact sites.

Main Results:

  • The NVJ exhibits plastic responses to metabolic cues, altering its architecture and proteome.
  • NVJ-resident proteins can localize to other contact sites under metabolic control.
  • The NVJ serves as a model for understanding contact site regulation.

Conclusions:

  • The NVJ is a multifunctional and metabolically plastic organelle contact site.
  • Understanding the NVJ provides insights into general principles of contact site regulation.
  • The NVJ is intricately connected with other cellular structures, highlighting its importance in cellular communication.