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Related Concept Videos

Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Pyloric Obstruction01:11

Pyloric Obstruction

Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...

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Related Experiment Video

Updated: Jul 1, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Clinical progress note: Rotavirus.

Kelsey Thetford1, Meghan Hofto1

  • 1Division of Hospital Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Journal of Hospital Medicine
|June 30, 2026
PubMed
Summary
This summary is machine-generated.

Rotavirus gastroenteritis, a common childhood illness, can cause severe dehydration. Vaccination significantly reduces hospitalizations, but awareness remains crucial for healthcare providers, especially with upcoming CDC guideline changes.

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Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins
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Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

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Last Updated: Jul 1, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins
11:40

Simplified Reverse Genetics Method to Recover Recombinant Rotaviruses Expressing Reporter Proteins

Published on: April 17, 2020

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Vaccinology

Background:

  • Rotavirus is a leading cause of acute viral gastroenteritis in children globally.
  • Severe rotavirus infections can lead to dehydration and electrolyte imbalances, posing significant risks to infants and young children.
  • High communicability and severity of initial infection make rotavirus a concern for seasonal outbreaks.

Purpose of the Study:

  • To highlight the continued importance of rotavirus recognition and management in pediatric hospital settings.
  • To inform healthcare providers about the impact of rotavirus vaccination and upcoming guideline changes.
  • To emphasize the ongoing relevance of rotavirus infection control despite vaccination efforts.

Main Methods:

  • This is a review and commentary based on existing literature and public health recommendations.
  • Analysis of the impact of rotavirus vaccine introduction on disease burden.
  • Discussion of clinical presentation, complications, and management strategies for rotavirus infections.

Main Results:

  • Rotavirus vaccination has substantially decreased infant hospitalizations due to rotavirus infections.
  • Despite vaccination, rotavirus remains a significant public health concern requiring ongoing surveillance and management.
  • Upcoming changes to CDC vaccine recommendations necessitate continued provider education.

Conclusions:

  • Rotavirus vaccination is highly effective in preventing severe gastroenteritis and reducing hospitalizations.
  • Healthcare providers must maintain vigilance in diagnosing and managing rotavirus infections, particularly in vulnerable populations.
  • Adaptation to evolving vaccine recommendations is essential for optimal public health outcomes.