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Updated: Jul 1, 2026

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
08:46

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Published on: December 9, 2015

Molecular studies on the impact of microbiome on anticancer drug resistance

Ke Zhou1,2,3, Ping Lu1,2,3, Hongli Xu1,2,3

  • 1Department of Abdominal Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Immunology
|June 30, 2026
PubMed

Insights

The gut microbiome significantly impacts cancer drug resistance by altering drug metabolism and immune responses. Targeting the microbiome offers new strategies to improve anticancer therapy effectiveness.

Area of Science:

  • Oncology
  • Microbiology
  • Pharmacology

Background:

  • Cancer drug resistance limits treatment efficacy.
  • The gut microbiome influences various biological processes.
  • Microbiome-cancer therapy interactions are increasingly recognized.

Purpose of the Study:

  • To review molecular mechanisms of microbiome-driven anticancer drug resistance.
  • To discuss emerging microbiome-targeted therapeutic strategies.

Main Methods:

  • Literature review and synthesis of current research.
  • Analysis of host-microbiome-drug interactions.

Main Results:

  • The gut microbiome modulates anticancer drug efficacy through biotransformation, immune modulation, and TME alteration.
  • Specific bacteria and microbial metabolites contribute to drug resistance.
  • Microbiome dysbiosis can promote resistance by affecting host pathways.

Conclusions:

  • Understanding host-microbiome-drug interactions is crucial for overcoming resistance.
  • Microbiome-targeted strategies hold promise for enhancing precision oncology.
Keywords:
anticancer drug resistancebiotransformationgut microbiomeimmunomodulationmicrobial metabolites

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