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Multidisciplinary management promoting wound healing in a patient with Proteus syndrome: a case report

Yue Tan1, Xu Zhang2, Hai-Bin Wang2

  • 1Clinical Pharmacy Department, Affiliated Hospital of Jining Medical University, Jining, China.

Frontiers in Pediatrics
|June 30, 2026
PubMed

Insights

Proteus syndrome, a rare genetic disorder caused by AKT1 gene mutations, presents unique challenges in diagnosis and treatment. This case highlights successful management of a severe infection in a young patient, emphasizing individualized care.

Area of Science:

  • Genetics
  • Clinical Medicine
  • Pharmacology

Background:

  • Proteus syndrome is a rare genetic disorder caused by AKT1 gene mutations, characterized by asymmetric overgrowth.
  • It often presents in childhood with nonspecific symptoms, leading to delayed diagnosis and lack of targeted treatments.
  • The condition carries a poor survival rate and significant morbidity due to its complex manifestations.
Abstract

Keywords:
congenital abnormalitiesinfectionpediatric diseasepharmacistproteus syndrome

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