Sigmoid Colon Metastasis from Endometrioid Carcinoma after a Long Disease-Free Interval Following Radiotherapy for...

Colorectal metastasis from endometrioid carcinoma is exceedingly uncommon and has been reported only in isolated case reports. We describe a case of sigmoid colon metastasis occurring after a long disease-free interval following radiotherapy for vaginal recurrence.

A 76-year-old woman presented with bloody stool. She had undergone hysterectomy for endometrioid carcinoma 9 years ago and had achieved a complete response after chemotherapy and radiotherapy for vaginal recurrence 5 years ago. Colonoscopy revealed a circumferential tumor at the sigmoid-descending colon junction, and laparoscope-assisted sigmoidectomy was performed. Postoperative pathological and immunohistochemical examinations demonstrated that the lesion represented metastatic endometrioid carcinoma. The patient subsequently received adjuvant paclitaxel plus carboplatin and has remained disease-free for 25 months.

This case shows that distant colorectal metastasis may occur even after a long disease-free interval following treatment for endometrioid carcinoma. Careful evaluation for late recurrence remains important, and complete surgical resection may provide effective disease control when metastasis is limited and amenable to resection.