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Screening Assay for Oxidative Stress in a Feline Astrocyte Cell Line, G355-5
Published on: July 13, 2011
Ozonized sunflower oil as an integrative therapy for feline sporotrichosis: a randomized clinical trial
Lucile S L Baía1, Beni J M Chaúque1, Régis A Zanette1
1Graduate Program in Biological Sciences: Pharmacology and Therapeutics, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Background:
Feline sporotrichosis, primarily caused by Sporothrix brasiliensis, is a zoonotic fungal infection with limited therapeutic options.
Aim:
This study evaluated the efficacy of ozonized sunflower oil (OSO) as an adjunct to itraconazole (ITZ) in 50 cats with sporotrichosis.
Methods:
Animals were randomized into two groups: ITZ alone (100 mg/cat once daily, n = 25) and ITZ plus topical OSO (700 meq/kg peroxide index, once daily, n = 25). Primary outcomes (wound healing time) and secondary outcomes (relapse rate) were assessed over 120 days.
Results:
Although the healing times were similar (ITZ: 29.04 ± 20.43 days; ITZ + OSO: 28.95 ± 11.41 days; p = 0.986), the ITZ + OSO group showed lower relapse rates (19.05% vs. 47.06%, p = 0.135) and delayed recurrence (48.67 vs. 27.62 days, p = 0.142). Notably, no relapses occurred in cats positive for feline immunodeficiency virus treated with ITZ + OSO (p = 0.0027).
Conclusion:
The immunomodulatory and antifungal properties of OSO may enhance therapeutic outcomes, particularly in immunocompromised animals.
