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Related Concept Videos

Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Microbial Corrosion01:24

Microbial Corrosion

Microbiologically Influenced Corrosion (MIC) is a significant form of material degradation caused by the metabolic activities of microorganisms. This phenomenon poses substantial challenges across various industries, including oil and gas, maritime, and water treatment sectors.MIC occurs when microorganisms, such as bacteria, archaea, and fungi, colonize metal surfaces, forming biofilms that alter the local electrochemical environment. These biofilms can lead to the production of corrosive...

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Updated: Jul 1, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
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A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries

Published on: December 27, 2016

Surfactant-Engineered Niosomal Antibiotic Systems for Biofilm-Associated Infections: Design Principles and

Siti Rahma1,2, Eri Amalia3, Sri Agung Fitri Kusuma2

  • 1Master Program of Pharmacy, Faculty of Pharmacy, Padjadjaran University, Sumedang, West Java, Indonesia.

International Journal of Nanomedicine
|June 30, 2026
PubMed
Summary

This review explores surfactant-engineered niosomes for treating microbial biofilm infections. Rational design of these nanocarriers can overcome biofilm barriers, improving antibiotic delivery and efficacy.

Keywords:
antibiotic deliverybiofilm-associated infectionsniosomessurfactant engineeringtranslational nanomedicinevesicular nanocarriers

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Published on: June 3, 2022

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Enhanced Oil Recovery using a Combination of Biosurfactants

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Area of Science:

  • Pharmaceutics
  • Materials Science
  • Microbial Pathophysiology

Background:

  • Microbial biofilms present significant challenges to antimicrobial therapy, reducing antibiotic efficacy and causing chronic infections.
  • Existing nanocarrier systems are often empirically developed, neglecting specific biofilm barriers.
  • Device-associated infections are particularly impacted by reduced antibiotic efficacy and relapse.

Purpose of the Study:

  • To review surfactant-engineered niosomal antibiotic systems from a rational design perspective.
  • To examine how formulation parameters influence niosome behavior within biofilms.
  • To propose a framework for designing advanced antibiofilm nanomedicine.

Main Methods:

  • Review of literature on surfactant-engineered niosomes for biofilm infections.
  • Analysis of formulation parameters (surfactant type, HLB, cholesterol, charge) and their impact.
  • Discussion of electrostatic and pH-responsive strategies for intrabiofilm delivery.

Main Results:

  • Key formulation parameters critically affect niosome properties like rigidity, permeability, and drug release.
  • Electrostatic interactions with the extracellular polymeric substance (EPS) matrix and pH-responsive release are crucial for localized delivery.
  • Promising in vitro antibiofilm activity is noted, but translational progress is limited.

Conclusions:

  • Rational design of surfactant-engineered niosomes is essential for overcoming biofilm barriers.
  • Further research needs to address formulation characterization, in vivo validation, and carrier-biofilm microenvironment alignment.
  • A structured framework can advance the development of effective antibiofilm nanomedicine.