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Related Concept Videos

Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 

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Fibrosis-4 and Aspartate Aminotransferase-to-Platelet Ratio Index as Predictors of Relapse in Autoimmune Hepatitis: A Retrospective Single-Center Study.

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Updated: Jul 1, 2026

Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
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Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin

Published on: September 12, 2019

Targeting TARDBP to Restore Colonic Barrier Integrity in Ulcerative Colitis via NFATC1 mRNA Destabilization.

Yin Jiang1, JingLin Gao1, YaLi Huang1

  • 1Department of Rheumatology and Immunology, Liuzhou Key Laboratory of Prevention and Treatment of Rheumatic Diseases, The Fourth Affiliated Hospital of Guangxi Medical University (Liuzhou Worker's Hospital), Liuzhou, China.

The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
|June 30, 2026
PubMed
Summary

The RNA-binding protein TARDBP reduces inflammation in ulcerative colitis by degrading NFATC1 mRNA. This TARDBP-NFATC1 pathway offers a potential therapeutic target for improving intestinal barrier function.

Keywords:
Cytoplasmic 1TAR DNA-binding proteindextran sulfate sodiumnuclear factor of activated T-cellsulcerative colitis

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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
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Published on: January 5, 2017

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Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin
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Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Area of Science:

  • Gastroenterology
  • Molecular Biology
  • Immunology

Background:

  • Ulcerative colitis (UC) involves impaired intestinal barrier function.
  • Post-transcriptional regulation of barrier integrity in UC is poorly understood.
  • NFATC1's role in UC barrier modulation requires investigation.

Purpose of the Study:

  • Investigate NFATC1's role in colonic barrier function during colitis.
  • Identify RNA-binding proteins that regulate NFATC1 expression.
  • Explore therapeutic targets for UC.

Main Methods:

  • Established a mouse model of UC using dextran sulfate sodium (DSS).
  • Utilized adeno-associated virus vectors for in vivo NFATC1 knockdown and TARDBP overexpression.
  • Assessed colonic pathology, apoptosis, inflammation, oxidative stress, and intestinal permeability.
  • Quantified gene and protein expression using RT-qPCR, western blotting, and immunofluorescence.
  • Investigated TARDBP-NFATC1 interaction via coimmunoprecipitation and RNA immunoprecipitation.

Main Results:

  • DSS-induced colitis impaired colonic barrier integrity, increasing NFATC1 and decreasing TARDBP.
  • NFATC1 knockdown or TARDBP overexpression ameliorated DSS-induced colonic damage.
  • TARDBP directly bound NFATC1 mRNA, promoting its degradation and reducing stability.
  • TARDBP's protective effect was diminished by simultaneous NFATC1 overexpression.

Conclusions:

  • Identified a novel post-transcriptional mechanism where TARDBP attenuates colonic inflammation.
  • TARDBP reduces inflammation by destabilizing NFATC1 mRNA.
  • The TARDBP-NFATC1 axis is a potential therapeutic target for UC and intestinal barrier restoration.