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Related Experiment Video

Updated: Jul 1, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Nanocomplex-Integrated Multifunctional Hydrogel for Fast-Tracked Wound Repair Application: A Preclinical Evaluation.

Shreyash Apotikar1, Aniruddha Dan1, Sebika Panja1

  • 1Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat 382355, India.

ACS Applied Bio Materials
|June 30, 2026
PubMed
Summary

Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...

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This summary is machine-generated.

This study presents a novel injectable hydrogel for deep wound healing. The gellan gum hydrogel, enhanced with a cerium-rutin nanocomplex, effectively scavenges reactive oxygen species and promotes faster wound closure.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Deep wounds often heal slowly due to excessive reactive oxygen species (ROS) that hinder tissue regeneration.
  • Current treatments face challenges in effectively managing ROS and promoting complete healing.

Purpose of the Study:

  • To develop an injectable hydrogel capable of scavenging ROS and accelerating deep wound healing.
  • To incorporate a cerium-rutin (Ce-R) nanocomplex into a gellan gum hydrogel for enhanced therapeutic effects.

Main Methods:

  • Gellan gum was crosslinked with 1,4-phenylenediboronic acid (PBA) to form boronate ester linkages.
  • A cerium-rutin (Ce-R) nanocomplex was synthesized and incorporated into the hydrogel network.
  • Physicochemical properties, antioxidant capacity, injectability, swelling, antimicrobial efficacy, and in vivo wound healing were evaluated.
Keywords:
ceriumgellan gumhydrogelinjectablerutinwound healing

Related Experiment Videos

Last Updated: Jul 1, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Main Results:

  • The developed hydrogel demonstrated significant ROS-scavenging capacity and broad-spectrum antimicrobial activity.
  • In vitro and in vivo studies confirmed the hydrogel's hemocompatibility, injectability, and swelling properties.
  • Rat wound models showed significantly accelerated wound closure, indicating enhanced healing.

Conclusions:

  • The Ce-R loaded boronate ester crosslinked gellan gum hydrogel is a promising therapeutic agent for deep wound healing.
  • This innovative hydrogel effectively addresses ROS-induced healing impairment and promotes tissue regeneration.