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Updated: Jul 1, 2026
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Nanocomplex-Integrated Multifunctional Hydrogel for Fast-Tracked Wound Repair Application: A Preclinical Evaluation
Shreyash Apotikar1, Aniruddha Dan1, Sebika Panja1
1Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Gandhinagar, Gujarat 382355, India.
ACS Applied Bio Materials
|June 30, 2026
Summary
This study presents a novel injectable hydrogel for deep wound healing. The gellan gum hydrogel, enhanced with a cerium-rutin nanocomplex, effectively scavenges reactive oxygen species and promotes faster wound closure.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Deep wounds often heal slowly due to excessive reactive oxygen species (ROS) that hinder tissue regeneration.
- Current treatments face challenges in effectively managing ROS and promoting complete healing.
Purpose of the Study:
- To develop an injectable hydrogel capable of scavenging ROS and accelerating deep wound healing.
- To incorporate a cerium-rutin (Ce-R) nanocomplex into a gellan gum hydrogel for enhanced therapeutic effects.
Main Methods:
- Gellan gum was crosslinked with 1,4-phenylenediboronic acid (PBA) to form boronate ester linkages.
- A cerium-rutin (Ce-R) nanocomplex was synthesized and incorporated into the hydrogel network.
- Physicochemical properties, antioxidant capacity, injectability, swelling, antimicrobial efficacy, and in vivo wound healing were evaluated.
Main Results:
- The developed hydrogel demonstrated significant ROS-scavenging capacity and broad-spectrum antimicrobial activity.
- In vitro and in vivo studies confirmed the hydrogel's hemocompatibility, injectability, and swelling properties.
- Rat wound models showed significantly accelerated wound closure, indicating enhanced healing.
Conclusions:
- The Ce-R loaded boronate ester crosslinked gellan gum hydrogel is a promising therapeutic agent for deep wound healing.
- This innovative hydrogel effectively addresses ROS-induced healing impairment and promotes tissue regeneration.
