Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
The Evidence for Evolution02:55

The Evidence for Evolution

Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.The collection of fossils within sedimentary rocks give a record of common ancestry and often depicts the history of evolution.
Methods of Documentation V: CBE01:23

Methods of Documentation V: CBE

Charting by Exception, or CBE, is a method of documentation used in healthcare, particularly in nursing, that focuses on documenting only significant or abnormal findings rather than recording every detail. This approach aims to streamline the documentation process, improve efficiency, and ensure that healthcare providers can quickly identify deviations from normalcy in patient assessments.
In CBE, healthcare professionals establish predefined standards of practice that define what constitutes...
Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
Hierarchy of Motor Control01:18

Hierarchy of Motor Control

The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic illness...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

bio.tools: an expanded web service for research software in the life sciences.

Nucleic acids research·2026
Same author

Ancient conservation of androglobin expression reveals its evolutionary link to ciliary processes.

Molecular biology and evolution·2026
Same author

Proteomic Mapping of Allergenic Proteins Reveals Key Differences Between Black Tiger Prawn (<i>Penaeus monodon</i>) and White Leg Prawn (<i>Litopenaeus vannamei</i>).

Journal of proteome research·2026
Same author

Potent reaction hijacking inhibitors of <i>Plasmodium falciparum</i> asparagine tRNA synthetase.

bioRxiv : the preprint server for biology·2026
Same author

Cargo Secreted by the Type IX Secretion System of Porphyromonas gingivalis Are Tethered to O-Lipopolysaccharides via a Pentasaccharide Linker.

MicrobiologyOpen·2026
Same author

Open and sustainable AI: challenges, opportunities and the road ahead in the life sciences.

Nature methods·2026
Same journal

Computationally Efficient Bayesian Estimation of Graphical Networks for Omics Data.

Journal of proteome research·2026
Same journal

Proteomic Profiling of Exosomes from HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma: Selective Cargo Packaging.

Journal of proteome research·2026
Same journal

Proteomic Analysis Identifies ATE1-Dependent Arginylation Dysregulation across Meningioma Grades.

Journal of proteome research·2026
Same journal

Proteomic Impact of Peripheral Expression of Mutant Huntingtin in <i>C. elegans</i>.

Journal of proteome research·2026
Same journal

Phosphorylation Patterns of Preribosomal Proteins Associated with the RNA Exosome.

Journal of proteome research·2026
Same journal

Tissue Proteomic Signatures of <i>BRAF</i>-Mutated Colorectal Cancer Reveal New Insights into Aggressiveness, Immune Modulation, and Metabolic Reprogramming.

Journal of proteome research·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Hierarchy of MS-Based Evidence.

Charlotte Adams1, Michael G Leeming2, David Teschner3

  • 1Adrem Data Lab, Department of Computer Science, University of Antwerp, 2020 Antwerpen, Belgium.

Journal of Proteome Research
|June 30, 2026
PubMed
Summary
This summary is machine-generated.

Scientific confidence in proteomics requires verifiable raw mass spectrometry (MS) data. A proposed evidence hierarchy will enhance trust by assessing data provenance and traceability, safeguarding against simulated datasets.

Related Experiment Videos

Last Updated: Jul 1, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Area of Science:

  • Proteomics
  • Computational Biology
  • Data Science

Background:

  • Scientific reproducibility hinges on verifiable primary observations.
  • Proteomics relies on public deposition of raw mass spectrometry (MS) data for reanalysis.
  • Advances in MS data simulation software pose risks to data integrity.

Purpose of the Study:

  • To address the vulnerability of MS data to alteration or in silico generation.
  • To propose a hierarchy of evidence for MS-based reporting.
  • To enhance trust and robustness in published proteomics findings.

Main Methods:

  • Developing a hierarchy of evidence for MS data reporting.
  • Analogous to established hierarchies in medicine.
  • Focusing on traceability and verifiable provenance of raw data files.

Main Results:

  • Current standards do not adequately differentiate raw data formats regarding provenance.
  • A proposed hierarchy offers a framework for assessing data integrity.
  • The framework aims to increase confidence in reported proteomics findings.

Conclusions:

  • A hierarchy of evidence is crucial for validating MS data.
  • Enhanced data provenance safeguards against fraudulent or simulated results.
  • Strengthening data integrity in proteomics is essential for scientific trust.