Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
Determinants of Bacterial Pathogenicity and Virulence01:20

Determinants of Bacterial Pathogenicity and Virulence

Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Breaking barriers: Implementation of a tuberculosis preventive treatment protocol among newly eligible populations with promising results.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2026
Same author

Development and Application of a Desirability of Outcome Ranking (DOOR) Endpoint for Acute Bacterial Skin and Skin Structure Infections.

Open forum infectious diseases·2026
Same author

Timing of Bronchoscopy and Plasma Microbial Cell-Free DNA Sequencing in Immunocompromised Host Pneumonia.

Open forum infectious diseases·2026
Same author

Treating penicillin-susceptible Staphylococcus aureus bacteraemia: confusing the issue with facts.

Lancet (London, England)·2026
Same author

The impact of follow-up blood cultures on mortality and management in patients with gram-negative bloodstream infections: a validation cohort study.

BMC infectious diseases·2026
Same author

West Nile Virus as a Trigger for Cardiovascular Diseases: A Meta-summary of Case Reports.

Journal of cardiovascular echography·2026
Same journal

Lineage dynamics and risk factors underlying serotype 4 invasive pneumococcal disease in Spain.

The Journal of infectious diseases·2026
Same journal

Tuberculosis in pregnancy: Challenges of immune protection.

The Journal of infectious diseases·2026
Same journal

Longitudinal Serum Metabolomic Signatures Related to Integrase Strand Transfer Inhibitors-Associated Weight Gain in Women with HIV Enrolled in the MACS/WIHS Combined Cohort Study.

The Journal of infectious diseases·2026
Same journal

Authors' Reply: Diagnostic Accuracy of Commercial Large Language Models for Anogenital Skin Lesion Images.

The Journal of infectious diseases·2026
Same journal

Methodological Considerations in Evaluating Large Language Models for Anogenital Lesion Diagnosis.

The Journal of infectious diseases·2026
Same journal

A comparative analysis of the immunotranscriptomic features of DENV-1, -3, and -4 human challenge models.

The Journal of infectious diseases·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2026

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
08:03

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus

Published on: March 28, 2017

Rationalising heterogeneity in Staphylococcus aureus bacteraemia: current progress and future goals.

Clark D Russell1,2,3, Sofía De La Villa4,5, Maaike C Swets6

  • 1Centre for Inflammation Research, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh, Scotland, United Kingdom.

The Journal of Infectious Diseases
|June 30, 2026
PubMed
Summary
This summary is machine-generated.

Investigating Staphylococcus aureus bacteraemia (SAB) as one disease hinders treatment. Stratifying SAB patients into distinct subphenotypes using data-driven methods is key for better therapies and outcomes.

Keywords:
Staphylococcus aureus bacteraemiaendotypespatient stratificationpersonalised medicinesubphenotypes

Related Experiment Videos

Last Updated: Jul 1, 2026

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus
08:03

A Tandem Liquid Chromatography–Mass Spectrometry-based Approach for Metabolite Analysis of Staphylococcus aureus

Published on: March 28, 2017

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Medical Informatics

Background:

  • Staphylococcus aureus bacteraemia (SAB) presents significant clinical and biological heterogeneity.
  • Treating SAB as a monolithic entity impedes the development of effective therapeutic strategies.

Purpose of the Study:

  • To review and compare recent data-driven patient stratification approaches for SAB.
  • To discuss the limitations of current methods and propose future research directions.
  • To highlight the importance of addressing heterogeneity for advancing SAB management.

Main Methods:

  • Comparison of methodologies from three recent studies (Swets et al, FEN-AUREUS, MRSA-GEIRAS-SEIMC) utilizing routinely available data for SAB patient stratification.
  • Analysis of findings related to mortality, microbiologic outcomes, and response to adjunctive therapies.

Main Results:

  • Three distinct data-driven approaches identified clinically relevant SAB subphenotypes.
  • These subphenotypes exhibit variations in mortality, treatment response, and microbiological outcomes.
  • The studies underscore the potential of patient stratification in optimizing SAB management.

Conclusions:

  • Addressing clinical and biological heterogeneity in SAB is crucial for transformative advances.
  • Progress requires moving from observable clinical subphenotypes to mechanism-based endotypes.
  • Future research should focus on refining stratification methods and identifying treatable traits.