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Beyond the Fixed Grid: Precision-guided Botulinum Toxin Treatment for Primary Axillary Hyperhidrosis

Muhammed Said Aydin1, Gökay Özler1

  • 1Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Türkiye.

Aesthetic Surgery Journal
|June 30, 2026
PubMed
Summary

No abstract available in PubMed .

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Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...