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Updated: Jul 1, 2026

Studying Inherited Immunity in a Caenorhabditis elegans Model of Microsporidia Infection
Published on: April 6, 2022
Ancestry Matters in Decoding Immunity
Kesong Wu1, Amanda J Oliver2, Zewen Kelvin Tuong1
1Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, South Brisbane, Queensland, Australia.
Abstract:
The Chinese Immune Multi-Omics Atlas (CIMA) establishes a population-scale immune multi-omics atlas by profiling over 10 million peripheral blood mononuclear cells from 428 Chinese adults using paired scRNA-seq and scATAC-seq. This resource mitigates longstanding European ancestry bias in single-cell genomics and enables cell type resolved regulatory mapping across immune populations. Building on this atlas, CIMA-CLM integrates chromatin sequence features with single-cell transcriptomic context to predict chromatin accessibility and assess noncoding variant effects, exemplified in FOXP3+ regulatory T cells.
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