Beyond the Surface: Decoding the Histopathological Spectrum of Hyperpigmented Skin Lesions in a Tertiary Care Center

Hyperpigmented skin lesions are a frequent reason for dermatology consultation in darker skin types. Many conditions share similar clinical appearances, making it difficult to distinguish benign from potentially serious disorders on examination alone.

The objectives of this study were to describe the clinical profile and histopathological patterns of hyperpigmented skin lesions in a South Indian population and to assess clinicopathological correlation across major diagnostic categories.

This cross-sectional study included 82 consecutive patients with clinically evident hyperpigmented lesions who underwent skin biopsy in a tertiary care center. Detailed sociodemographic, clinical, and exposure data were recorded. Biopsies were evaluated for epidermal changes, interface pattern, pigment incontinence, dermal inflammatory pattern, and melanophages.

Patients had a wide age range (mean: 41.8 years) with a slight female predominance. Lesions were generally chronic; nearly half were symptomatic and commonly involved the trunk and face. Preceding inflammatory dermatoses, moderate-to-high sun exposure, cosmetic use, fairness creams, topical steroid application, and alternative medicine use were frequent.

In this cohort, hyperpigmented lesions were largely driven by interface-related dermal pigmentation and postinflammatory change. Clinical diagnosis was generally reliable for lichenoid disorders and nevi but less accurate for postinflammatory hyperpigmentation and melasma, highlighting the continuing need for biopsy in equivocal or high-risk pigmented lesions and for attention to modifiable exposure-related triggers.