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Examination of Pyroptosis by Flow Cytometry
Published on: May 31, 2024
Gasdermin E: Bridging Pyroptosis, Immunity, and Disease Pathogenesis Toward Precision Intervention
Ping Wang1, Chuandan Wan2, Yeqiong Xu2
1School of Basic Medical Sciences, Wannan Medical University, Wuhu, 241002, China.
The Protein Journal
|June 30, 2026
Summary
Gasdermin E (GSDME) regulates immune responses and cell death, acting as a tumor suppressor or pro-inflammatory mediator. Understanding its dual roles is key for developing targeted therapies in cancer and inflammatory diseases.
Area of Science:
- Immunology
- Cell Biology
- Molecular Medicine
Background:
- Gasdermin E (GSDME) is a key pyroptosis executor involved in immune responses.
- Initially identified as a tumor suppressor (DFNA5), GSDME has complex roles in disease.
Purpose of the Study:
- To review GSDME's structure, activation pathways (canonical and non-canonical), and dual functions.
- To evaluate GSDME's potential as a biomarker and therapeutic target across diseases.
- To analyze strategies for modulating GSDME activity for therapeutic benefit.
Main Methods:
- Literature review synthesizing current research on GSDME.
- Systematic dissection of GSDME's functions in cancer, inflammation, neurodegeneration, and organ injury.
- Critical analysis of pharmacological strategies targeting GSDME.
Main Results:
- GSDME activation via caspase-3 cleavage triggers pro-inflammatory pyroptosis.
- GSDME exhibits context-dependent dual roles, acting as a tumor suppressor or promoting inflammation.
- Emerging non-canonical pathways and diverse therapeutic strategies are being explored.
Conclusions:
- GSDME is a critical regulator of immunity and cell death with significant therapeutic potential.
- Targeting GSDME offers opportunities for precision medicine in oncology and inflammatory diseases.
- Further research is needed for clinical translation of GSDME-targeted therapies.
