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NUT Carcinoma Arising in Stensen's Duct: First Reported Case and Literature Review
Mariel Bedell1, Seungwon Kim2, Mana Mohebnasab3
1Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. mbedell11@gmail.com.
Head and Neck Pathology
|June 30, 2026
Summary
This report details the first NUT carcinoma originating from Stensen's duct, a rare salivary gland cancer. The case highlights diagnostic challenges and suggests a link between NUT carcinoma and homologous recombination deficiency.
Area of Science:
- Oncology
- Genetics
- Pathology
Background:
- NUT carcinoma is a rare, aggressive cancer defined by NUTM1 gene rearrangements.
- Carcinomas of Stensen's duct are exceedingly rare, with limited reported cases and diverse morphologies.
Purpose of the Study:
- To report the first documented case of NUT carcinoma arising from Stensen's duct.
- To discuss the diagnostic complexities and potential molecular associations of this rare malignancy.
Main Methods:
- Case presentation of a 37-year-old female with a Stensen's duct mass.
- Utilized imaging, biopsy, immunohistochemistry, FISH, and RNA sequencing for diagnosis.
- Confirmed NUTM1 translocation and identified a BRD4::NUTM1 fusion.
- Detected a germline BRCA1 mutation.
Main Results:
- Diagnosed as NUT carcinoma with a BRD4::NUTM1 fusion.
- The patient underwent resection, chemotherapy, and radiation with no evidence of disease post-treatment.
- Identified a concurrent germline BRCA1 mutation, indicating homologous recombination deficiency.
Conclusions:
- This case expands the known spectrum of Stensen's duct carcinomas.
- Highlights diagnostic challenges in interpreting parotid region masses.
- Suggests a potential association between NUT carcinoma and homologous recombination deficiency (HRD).
