Related Experiment Video
Updated: Jul 1, 2026
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Small Intestinal Bacterial Overgrowth: Microbiome Dysregulation, Gut-Brain Axis Disruption, and Systemic
Ayman Furqan1, Muhammad Tauseef Sultan1, Muhammad Usman Khalid1,2
1Faculty of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan.
Molecular Nutrition & Food Research
|June 30, 2026
Summary
Small intestinal bacterial overgrowth (SIBO) impacts multiple body systems. While treatments like antibiotics and diet exist, research is needed for better diagnostics and personalized therapies to prevent SIBO recurrence.
Area of Science:
- Gastroenterology
- Microbiology
- Internal Medicine
Background:
- Small intestinal bacterial overgrowth (SIBO) involves excessive bacteria in the small intestine, causing digestive issues and nutrient deficiencies.
- SIBO is increasingly linked to systemic conditions affecting metabolism, neurology, cardiovascular health, skin, and autoimmune disorders.
Purpose of the Study:
- To critically review the complex pathophysiology of SIBO.
- To synthesize current diagnostic and therapeutic strategies for SIBO.
- To identify research priorities for improved SIBO management and sustained remission.
Main Methods:
- Comprehensive literature review of SIBO pathophysiology, diagnostics, and therapeutics.
- Analysis of evidence supporting antibiotics, dietary interventions, and nutraceuticals.
- Identification of research gaps and future directions.
Main Results:
- SIBO pathophysiology involves gut-brain axis dysfunction, dysbiosis, oxidative stress, motility issues, and immune dysfunction.
- Current treatments include rifaximin, low-FODMAP/biphasic diets, and nutraceuticals, but face challenges like recurrence and resistance.
- Nutraceutical and dietary options show promise but need more clinical validation.
Conclusions:
- Effective SIBO management requires addressing its multifactorial nature, including gut-brain interactions and microbial balance.
- Further research is crucial for developing more effective, personalized treatments and diagnostics to reduce SIBO recurrence.
- Global clinical trials and microbiome-based approaches are key for advancing SIBO care.
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