Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate.
Studying the Cytoskeleton01:17

Studying the Cytoskeleton

The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Light-Driven Dual Rotary Molecular Motors and Beyond.

Accounts of chemical research·2026
Same author

Benzene at 200: from a simple ring to a universe of fused aromatic carbon.

Chemical science·2026
Same author

Temperature- and Light-Regulated Liquid Crystal Smart Window for Dynamic Control of Daylight and Solar Heat in All-Weather Conditions.

Angewandte Chemie (International ed. in English)·2026
Same author

Lipid nanoparticle formulations including stereochemically defined glycomacromolecules for delivery of saRNA.

Chemical science·2026
Same author

Engineering Highly Photoefficient and Function-Tunable Molecular Rotary Motors toward Sunlight Responsiveness.

Journal of the American Chemical Society·2026
Same author

Fully Reversible Photocontrol over DNA Intercalation with Visible Light.

Journal of the American Chemical Society·2026

Related Experiment Video

Updated: Jul 2, 2026

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
08:40

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

Utilizing Light to Control Glycopolymer-DC-SIGN Interactions via Molecular Motors.

Caitlin L A Nutting1, Adrien Combe2, Gokhan Yilmaz1

  • 1Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.

Journal of the American Chemical Society
|June 30, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed light-responsive molecular motors with attached sugars to control interactions with immune system proteins. This innovation allows tunable binding for targeted drug delivery in precision therapies.

More Related Videos

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
08:04

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Published on: January 26, 2019

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics
09:10

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics

Published on: August 25, 2022

Related Experiment Videos

Last Updated: Jul 2, 2026

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging
08:40

Light-driven Molecular Motors on Surfaces for Single Molecular Imaging

Published on: March 13, 2019

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins
08:04

Assembling Molecular Shuttles Powered by Reversibly Attached Kinesins

Published on: January 26, 2019

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics
09:10

Reconstituting and Characterizing Actin-Microtubule Composites with Tunable Motor-Driven Dynamics and Mechanics

Published on: August 25, 2022

Area of Science:

  • Biochemistry
  • Materials Science
  • Immunology

Background:

  • Molecular motors offer controlled rotation for applications in smart materials and biological systems.
  • Glycopolymers are used in lectin-binding for disease treatment but lack external stimulus adaptability.
  • Controlling carbohydrate-lectin interactions is crucial for targeted therapies.

Purpose of the Study:

  • To integrate multivalent glycopolymeric structures with first-generation molecular rotary motors.
  • To develop photoadaptive glycopolymer-based molecular motors functionalized with specific monosaccharides.
  • To investigate the impact of light-controlled motor conformation on lectin-binding properties.

Main Methods:

  • Synthesized photoadaptive glycopolymer-based first-generation molecular motors.
  • Functionalized motors with β-d-glucopyranoside and β-d-mannopyranoside.
  • Utilized surface plasmon resonance and competition assays with immune receptors and HIV gp120.

Main Results:

  • Light-induced conformational changes in molecular motors modulated glycopolymer binding affinity.
  • The binding affinity and half-maximal inhibitory concentration values were significantly affected by light.
  • Demonstrated control over carbohydrate-lectin interactions using light-driven molecular motors.

Conclusions:

  • Photoresponsive glycopolymer-based molecular motors can precisely control carbohydrate-lectin interactions.
  • Light-driven modulation of binding affinity opens avenues for advanced targeted therapeutics.
  • These findings highlight the potential of light-responsive glycopolymers in cell-specific drug delivery.