Related Experiment Video
Updated: Jul 2, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
Association between genetic ancestry and EDAR rs3827760 genotypes in Latin American populations
Jorge Briceño1, Ángel Roco-Videla2, Germán Maríquez-Soto3
1Centro de Análisis Cuantitativo en Antropología Dental, Instituto de Investigación en Ciencias Odontológicas, Facultad de Odontología, Universidad de Chile, Santiago, Chile.
Abstract:
Introduction. The EDAR (ectodysplasin A receptor) gene is associated with the development of ectodermal structures. The rs3827760 variant is highly frequent in East Asian and Native American populations, and this study analyzes its relationship with genetic ancestry proportions in a Latin American population sample. Objective. To analyze how genetic ancestry proportions influence the distribution of single nucleotide polymorphism (SNP) rs3827760 genotypes of the EDAR gene in Latin American populations. Materials and methods. Genetic ancestry proportions were estimated using a panel of 446 ancestry-informative SNPs, applying the STRUCTURE program and univariate and multivariate logistic regression models. Results. Native American ancestry proportions showed a significant positive association with the prevalence of rs3827760 GG genotypes, while European ancestry showed a negative association. Conclusion. Native American and European genetic ancestry proportions influence the distribution of SNP rs3827760 genotypes of the EDAR gene in Latin American populations.
Related Concept Videos
Genetic Lingo
Incomplete Dominance
Principles of Pharmacogenetics: Types of Genetic Variants
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...