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Updated: Jul 2, 2026
18:48
In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
Published on: August 12, 2017
CD4+CD25+FOXP3+ Regulatory T Cells to Protect Against Graft Versus Host Disease
Robert S Negrin1, Everett Meyer2
1Stanford University Medical Center, Stanford, California, United States.
Blood
|June 30, 2026
Summary
Allogeneic hematopoietic cell transplantation (HCT) shows promise for hematological disorders but faces challenges like graft-versus-host disease (GVHD). Regulatory T cells (Tregs) offer new hope for reducing transplant risks and expanding HCT eligibility.
Area of Science:
- Immunology
- Transplantation Medicine
- Hematology
Background:
- Allogeneic hematopoietic cell transplantation (HCT) is a vital treatment for hematological malignancies and bone marrow failure.
- Graft-versus-host disease (GVHD) and immune incompetence are major hurdles, increasing non-relapse mortality (NRM) and limiting HCT to high-risk patients.
- GVHD is a dysregulated immune response exacerbated by immunosuppression and lymphoid tissue injury.
Purpose of the Study:
- To review the history, preclinical studies, and clinical translation of CD4+CD25+FoxP3+ regulatory T cells (Tregs).
- To explore how advancements in understanding immune regulation can improve HCT outcomes.
- To discuss the potential of Tregs in reducing transplant-related risks for broader HCT application.
Main Methods:
- Literature review focusing on regulatory T cell biology and their application in allogeneic HCT.
- Analysis of preclinical studies investigating Treg efficacy and safety.
- Examination of clinical trial data on Treg-based therapies in HCT.
Main Results:
- Regulatory T cells (Tregs) are crucial for immune tolerance and preventing GVHD.
- Preclinical and early clinical studies demonstrate the potential of Tregs to mitigate GVHD and improve immune reconstitution post-HCT.
- Nobel Prize-recognized advancements in immune regulation provide a foundation for Treg-based therapeutic strategies.
Conclusions:
- CD4+CD25+FoxP3+ regulatory T cells (Tregs) represent a promising therapeutic strategy to overcome GVHD and immune incompetence in allogeneic HCT.
- Reducing transplant-related risks through Treg therapy could expand HCT eligibility to a wider patient population.
- Further research and clinical translation of Tregs are essential for realizing the full potential of HCT.
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