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Updated: Jul 9, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

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Published on: December 6, 2016

Evolution of daytime sleepiness and affective symptoms in patients with obstructive sleep apnea treated with

Stella Maris Valiensi¹, Agustín Folgueira¹

¹Hospital Italiano de Buenos Aires.

Revista De La Facultad De Ciencias Medicas (Cordoba, Argentina)

|June 30, 2026

Summary

Continuous Positive Airway Pressure (CPAP) therapy significantly reduces daytime sleepiness in patients. However, this study found no significant improvement in anxiety or depression symptoms with CPAP treatment.

Keywords:

depression drowsiness anxiety

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Published on: October 18, 2024

Area of Science:

Sleep Medicine
Psychiatry

Background:

Obstructive sleep apnea (OSA) is a common disorder characterized by repeated episodes of upper airway collapse during sleep.
Daytime sleepiness, anxiety, and depression are common symptoms associated with OSA.
Continuous Positive Airway Pressure (CPAP) is the gold standard treatment for OSA, primarily aimed at improving sleep quality and reducing daytime sleepiness.

Purpose of the Study:

To analyze and correlate subjective symptoms of daytime sleepiness, depression, and anxiety before and after CPAP treatment.
To evaluate the long-term effects of CPAP therapy on mood disorders and sleepiness.

Main Methods:

A retrospective, observational, longitudinal study was conducted.
Data was collected from questionnaires administered at three time points: initial diagnosis with polysomnography (PSG) and oximetry, and during Auto-CPAP titration.
Validated scales including the Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI), and a self-report anxiety scale were used.

Main Results:

A significant decrease in daytime sleepiness was observed over the study period, as measured by the Epworth Sleepiness Scale.
No statistically significant differences were found in anxiety (p=0.45) or depression (p=0.52) scores following CPAP treatment.
The findings indicate that while CPAP effectively manages sleepiness, its impact on mood disorders like anxiety and depression may be limited.

Conclusions:

CPAP therapy demonstrates efficacy in reducing daytime sleepiness in patients with sleep apnea.
CPAP treatment did not show a significant impact on improving symptoms of anxiety and depression in this patient cohort.
Healthcare providers should be aware of these findings to better understand the benefits of CPAP therapy regarding sleepiness and to inform clinical decision-making for comprehensive patient care.