Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitochondrial Membranes01:45

Mitochondrial Membranes

A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
The Electron Transport Chain01:30

The Electron Transport Chain

The electron transport chain or oxidative phosphorylation is an exothermic process in which free energy released during electron transfer reactions is coupled to ATP synthesis. This process is a significant source of energy in aerobic cells, and therefore inhibitors of the electron transport chain can be detrimental to the cell's metabolic processes.
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q in...
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
Translocation of Proteins into the Mitochondria01:19

Translocation of Proteins into the Mitochondria

Mitochondrial precursors are translocated to the internal subcompartments via independent mechanisms involving distinct protein machineries called translocases.
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Features of diet in patients with cardiometabolic diseases with gout and hyperuricemia: A review].

Terapevticheskii arkhiv·2025
Same author

[Evaluation of topical therapy of patients with osteoarthritis of small joints of the hands with Voltaren® Emulgel® 2% (diclofenac diethylamine 2%)].

Terapevticheskii arkhiv·2022
Same author

[Evaluation of a 12-week allopurinol-lowering therapy in combination with the non-steroidal anti-inflammatory drug meloxicam in patients with gout].

Terapevticheskii arkhiv·2020
Same journal

[History of the Moscow Scientific Society of Cardiology].

Terapevticheskii arkhiv·2026
Same journal

[Antiphospholipid syndrome: ophthalmologic manifestations. A review].

Terapevticheskii arkhiv·2026
Same journal

[Rheumatoid nodule in the myocardium as part of the chain in a clinical detective. Case report].

Terapevticheskii arkhiv·2026
Same journal

[Immunoglobulin G4-related retroperitoneal fibrosis: clinical, laboratory, imaging, and histopathological features in a Russian single-center cohort].

Terapevticheskii arkhiv·2026
Same journal

[Cutaneous manifestations of systemic lupus erythematosus and coexisting dermatologic conditions].

Terapevticheskii arkhiv·2026
Same journal

[Association of diabetes mellitus with high activity and radiographic progression of psoriatic arthritis].

Terapevticheskii arkhiv·2026
See all related articles

Related Experiment Video

Updated: Jul 2, 2026

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

[Uric acid and mitochondrial dysfunction: a review].

G V Grigorenko1, V V Tsurko1

  • 1Pirogov Russian National Research Medical University (Pirogov University).

Terapevticheskii Arkhiv
|June 30, 2026
PubMed
Summary
This summary is machine-generated.

Hyperuricemia, linked to high uric acid (UA) levels, can cause mitochondrial dysfunction. This review explores how UA disrupts cellular energy balance and increases oxidative stress, impacting cellular health.

Keywords:
fructosehomeostasishyperuricemiamitochondrial dysfunctionuric acid

More Related Videos

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
08:39

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides

Published on: September 16, 2020

Related Experiment Videos

Last Updated: Jul 2, 2026

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
09:40

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Published on: January 19, 2017

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides
08:39

Experimental Protocol for Detecting Mitochondrial Function in Hepatocytes Exposed to Organochlorine Pesticides

Published on: September 16, 2020

Area of Science:

  • Biochemistry
  • Cellular Biology
  • Metabolic Disorders

Background:

  • The link between hyperuricemia and mitochondrial dysfunction is not well-established.
  • Mitochondrial dysfunction has significant clinical implications.
  • Uric acid (UA) plays a role in cellular energy homeostasis.

Purpose of the Study:

  • To identify the causes and mechanisms of UA's influence on mitochondrial dysfunction.
  • To analyze the pathogenetic relationship between UA and mitochondrial dysfunction.
  • To examine the role of fructose metabolism in UA production and cellular energy regulation.

Main Methods:

  • Comprehensive literature review.
  • Analysis of pathogenetic mechanisms.
  • Examination of UA's role in oxidative stress and AMPK signaling.

Main Results:

  • UA's influence on mitochondrial dysfunction is an evolutionarily conserved process, now pathological.
  • Fructose metabolism significantly impacts UA levels and cellular energy balance.
  • UA increases oxidative stress, impairing mitochondrial function.
  • UA inhibits AMP-activated protein kinase (AMPK), leading to mitochondrial dysfunction.

Conclusions:

  • UA is a key factor in developing mitochondrial dysfunction.
  • Understanding UA's role in mitochondrial dysfunction is crucial for metabolic disorder treatment.
  • Targeting UA metabolism and AMPK signaling may offer therapeutic strategies.