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Tezepelumab in patients with asthma: a systematic review and meta-analysis of randomized controlled trials
Wenli Shang1, Guizuo Wang1, Dong Han1
1Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China.
Objective:
Current biological treatments are not suitable for many patients with severe asthma. The aim of this meta-analysis was to determine the efficacy of tezepelumab in patients with asthma.
Methods:
The authors conducted systematic searches of PubMed, Embase, the Cochrane Library, and clinicaltrials.gov without language restrictions. Randomized Controlled Trials (RCTs) on treatment of asthma with tezepelumab were reviewed. The authors summarized findings as Risk Ratios (RR) for dichotomous outcomes and Weighted Mean Differences (WMD) for continuous outcomes, each with 95% Confidence Intervals (95% CI).
Results:
Seven RCTs (enrolling 2050 participants) met the inclusion criteria. Tezepelumab showed significant effects on asthma exacerbation (RR = 0.72, 95% CI 0.65% to 0.80), percentage change in Forced Expiratory Volume in 1 s (FEV1) (WMD = 7.97%, 95% CI 3.10% to 13.83%), percentage change in Forced Vital Capacity (FVC) (WMD = 3.80%, 95% CI 2.48% to 5.12%), Asthma Control Questionnaire (ACQ)-6 score (WMD = -0.35, 95% CI -0.45 to -0.25), Asthma Quality of Life Questionnaire (standardized) for patients 12-years of age or older (AQLQ[S]+12) score (WMD = 0.33, 95% CI 0.22 to 0.43), and serious adverse events (RR = 0.74, 95% CI 0.57 to 0.95).
Conclusions:
Tezepelumab appears safe and effective; further long-term and real-world studies are warranted.
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