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Related Experiment Videos

Multiomics analyses in young grade C molar incisor pattern periodontitis.

Meaad M Alamri1, Gordon Proctor2, Fernando Garcia-Guevara2

  • 1Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom; Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

Journal of Dentistry
|June 30, 2026
PubMed
Summary

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Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...

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Young patients with severe periodontitis (C/MIP) exhibit a distinct dysbiotic microbiome and altered metabolic profile, with specific bacteria and metabolites potentially driving disease progression. This multi-omics study offers insights into C/MIP pathogenesis and identifies potential biomarkers.

Area of Science:

  • Oral microbiology
  • Metabolomics
  • Periodontology

Background:

  • Severe periodontitis in young patients (C/MIP) pathogenesis is complex.
  • Understanding the interplay between microbial and metabolic profiles is crucial.

Purpose of the Study:

  • To investigate microbial and metabolic profiles in young C/MIP patients.
  • To compare these profiles with healthy controls.
  • To integrate multi-omics data for elucidating C/MIP pathogenesis.

Main Methods:

  • Shotgun sequencing metagenomics for bacterial profiles in saliva and plaque.
  • Nuclear magnetic resonance and mass spectrometry for metabolic profiles in saliva and serum.
  • Multi-omics data integration and network visualization.
Keywords:
Microbiome–metabolite interactionsMolar-incisor patternPathogenesisPeriodontitisShotgun metagenomics

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Main Results:

  • C/MIP patients showed distinct salivary and serum metabolite alterations.
  • The plaque microbiome was enriched with pathogenic bacteria (e.g., D. oralis) and depleted of health-associated species.
  • Specific metabolites (e.g., DL-glutamine, taurine) were associated with periodontal pathogens.

Conclusions:

  • C/MIP is characterized by microbial dysbiosis and metabolic alterations.
  • Key pathogens and metabolites contribute to disease progression.
  • Multi-omics approach provides a foundation for understanding C/MIP and identifying biomarkers.