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Giant Omphalocele
Anastasia M Kahan1, Michelle J Yang2, Martha A Monson3
1Division of Pediatric Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, Utah.
Neoreviews
|June 30, 2026
Summary
Giant omphalocele (GO) is a rare abdominal wall defect requiring specialized care. This review covers prenatal diagnosis, neonatal management, surgical interventions, and long-term outcomes for GO patients.
Area of Science:
- Pediatric Surgery
- Neonatology
- Maternal-Fetal Medicine
Background:
- Omphalocele is the second most common congenital abdominal wall defect.
- Giant omphalocele (GO) involves herniation of abdominal viscera into a sac, often including over 50% of the liver.
- Pathophysiology involves failed abdominal wall closure and bowel return during embryogenesis.
Purpose of the Study:
- To review the prenatal, neonatal, and surgical management of giant omphalocele.
- To discuss the long-term outcomes for patients diagnosed with giant omphalocele.
Main Methods:
- Review of existing literature on giant omphalocele.
- Synthesis of information regarding diagnostic and management strategies.
- Analysis of long-term follow-up data.
Main Results:
- Prenatal diagnosis is typically achieved via ultrasonography.
- Management requires a multidisciplinary approach involving obstetrics, neonatology, and pediatric surgery.
- Surgical intervention and intensive neonatal care are crucial.
Conclusions:
- Giant omphalocele necessitates comprehensive, multidisciplinary care from prenatal diagnosis through long-term follow-up.
- Effective management strategies aim to improve outcomes for affected infants.
- Further research into pathophysiology and long-term outcomes is warranted.
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